Differential Expression Pattern of Retroviral Envelope Gene in the Equine Placenta.

RT-qPCR equine endogenous retrovirus horse in situ hybridization placenta

Journal

Frontiers in veterinary science
ISSN: 2297-1769
Titre abrégé: Front Vet Sci
Pays: Switzerland
ID NLM: 101666658

Informations de publication

Date de publication:
2021
Historique:
received: 10 04 2021
accepted: 09 06 2021
entrez: 26 7 2021
pubmed: 27 7 2021
medline: 27 7 2021
Statut: epublish

Résumé

Endogenous retroviruses (ERVs) are proviral phases of exogenous retroviruses, which have coevolved with vertebrate genomes for millions of years. The conservation of ERV genes throughout evolution suggests their beneficial effects on their hosts' survival. An example of such positive selection is demonstrated by the syncytin gene, which encodes a protein with affinity for various mammalian placentas that is involved in the formation of syncytiotrophoblasts. Although the horse has an epitheliochorial placenta, in which the fetal trophoblasts are simply apposed to the intact uterine epithelium, we have previously demonstrated that the equine ERV (EqERV)

Identifiants

pubmed: 34307531
doi: 10.3389/fvets.2021.693416
pmc: PMC8298818
doi:

Types de publication

Journal Article

Langues

eng

Pagination

693416

Informations de copyright

Copyright © 2021 Stefanetti, Pascucci, Wilsher, Cappelli, Capomaccio, Reale, Passamonti, Coletti, Crociati, Monaci and Marenzoni.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Valentina Stefanetti (V)

Department of Veterinary Medicine, University of Perugia, Perugia, Italy.

Luisa Pascucci (L)

Department of Veterinary Medicine, University of Perugia, Perugia, Italy.

Sandra Wilsher (S)

The Paul Mellon Laboratory of Equine Reproduction, 'Brunswick', Newmarket, United Kingdom.

Katia Cappelli (K)

Department of Veterinary Medicine, University of Perugia, Perugia, Italy.

Stefano Capomaccio (S)

Department of Veterinary Medicine, University of Perugia, Perugia, Italy.

Lara Reale (L)

Department of Agricultural, Food and Environmental Sciences, University of Perugia, Perugia, Italy.

Fabrizio Passamonti (F)

Department of Veterinary Medicine, University of Perugia, Perugia, Italy.

Mauro Coletti (M)

Department of Veterinary Medicine, University of Perugia, Perugia, Italy.

Martina Crociati (M)

Department of Veterinary Medicine, University of Perugia, Perugia, Italy.
Centre for Perinatal and Reproductive Medicine, University of Perugia, Perugia, Italy.

Maurizio Monaci (M)

Department of Veterinary Medicine, University of Perugia, Perugia, Italy.
Centre for Perinatal and Reproductive Medicine, University of Perugia, Perugia, Italy.

Maria Luisa Marenzoni (ML)

Department of Veterinary Medicine, University of Perugia, Perugia, Italy.

Classifications MeSH