A quinoxaline-based compound ameliorates bone loss in ovariectomized mice.

Animals Bone Density / drug effects Bone Resorption / drug therapy Disease Models, Animal Female Glucagon-Like Peptide 1 / metabolism Glucagon-Like Peptide-1 Receptor / agonists Menopause / physiology Mice Mice, Inbred C57BL Osteoclasts / drug effects Osteogenesis / drug effects Osteoporosis / drug therapy Quinoxalines / pharmacology
6,7-dichloro-2-methylsulfonyl-3-Ntert-butylaminoquinoxaline Osteoporosis bone metabolism glucagon-like peptide 1 receptor small molecule agonist

Journal

Experimental biology and medicine (Maywood, N.J.)
ISSN: 1535-3699
Titre abrégé: Exp Biol Med (Maywood)
Pays: England
ID NLM: 100973463

Informations de publication

Date de publication:
12 2021
Historique:
pubmed: 27 7 2021
medline: 28 12 2021
entrez: 26 7 2021
Statut: ppublish

Résumé

DMB (6,7-dichloro-2-methylsulfonyl-3-Ntert-butylaminoquinoxaline) is a quinoxaline-based compound that has been investigated as a glucagon-like peptide-1 receptor (GLP-1R) agonist. To clarify anti-osteoporosis effect of DMB, an osteoporotic mice model was established by ovariectomy (OVX) operation. The OVX mice were given intraperitoneally DMB, exendin-4 (EX-4), or 17β-estradiol (E

Identifiants

DOI: 10.1177/15353702211032133 PMID: 34308655 PMC: PMC8649934
pubmed: 34308655
doi: 10.1177/15353702211032133
pmc: PMC8649934
doi:

Substances chimiques

Glucagon-Like Peptide-1 Receptor 0
Quinoxalines 0
Glucagon-Like Peptide 1 89750-14-1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2502-2510

Références

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Auteurs

Ying Zhou (Y)

Department of Basic Medicine, Xi'an Medical University, Xi'an 710021, PR China.
Science and Technology Innovation Platform of Shaanxi Provincial Research Center for Project of Prevention and Treatment of Respiratory Diseases, Xi'an Medical University, Xi'an 710021, PR China.

Xiaoyan Xue (X)

Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi'an 710032, PR China.

Yanyan Guo (Y)

Precision Pharmacy & Drug Development Center, Department of Pharmacy, Tangdu Hospital, the Fourth Military Medical University, Xi'an 710038, PR China.

Huan Liu (H)

Department of Basic Medicine, Xi'an Medical University, Xi'an 710021, PR China.

Zheng Hou (Z)

Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi'an 710032, PR China.

Zhou Chen (Z)

Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi'an 710032, PR China.

Ning Wang (N)

Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi'an 710032, PR China.

Fen Li (F)

Department of Basic Medicine, Xi'an Medical University, Xi'an 710021, PR China.

Yang Wang (Y)

Department of Basic Medicine, Xi'an Medical University, Xi'an 710021, PR China.
ORCID: 0000-0003-4848-8503

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A quinoxaline-based compound ameliorates bone...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Densité osseuse › A quinoxaline-based compound ameliorates bone...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Résorption osseuse › A quinoxaline-based compound ameliorates bone...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › A quinoxaline-based compound ameliorates bone...
questionsmedicales.fr › Hormones gastrointestinales › Peptides glucagon-like › Glucagon-like peptide 1 › A quinoxaline-based compound ameliorates bone...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone gastrointestinale › Récepteurs des peptides similaires au glucagon › Récepteur du peptide-1 similaire au glucagon › A quinoxaline-based compound ameliorates bone...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Développement sexuel › Climatère › Ménopause › A quinoxaline-based compound ameliorates bone...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A quinoxaline-based compound ameliorates bone...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › A quinoxaline-based compound ameliorates bone...
questionsmedicales.fr › Cellules › Cellules myéloïdes › Ostéoclastes › A quinoxaline-based compound ameliorates bone...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Développement locomoteur › Biominéralisation › Développement osseux › Ostéogenèse › A quinoxaline-based compound ameliorates bone...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Maladies osseuses métaboliques › Ostéoporose › A quinoxaline-based compound ameliorates bone...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoxalines › A quinoxaline-based compound ameliorates bone...