Human Milk Antibodies Against SARS-CoV-2: A Longitudinal Follow-Up Study.
COVID-19
breastfeeding
coronavirus
immunoglobulins
lactation
mother’s own milk
secretory IgA
Journal
Journal of human lactation : official journal of International Lactation Consultant Association
ISSN: 1552-5732
Titre abrégé: J Hum Lact
Pays: United States
ID NLM: 8709498
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
pubmed:
27
7
2021
medline:
26
11
2021
entrez:
26
7
2021
Statut:
ppublish
Résumé
Human milk contains antibodies against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) following Coronavirus Disease 2019 (COVID-19). These antibodies may serve as protection against COVID-19 in infants. However, the evolution of these human milk antibodies over time is unclear. To elucidate the evolution of immunoglobulin A (IgA) against SARS-CoV-2 in human milk after a SARS-CoV-2 infection. This longitudinal follow-up study included lactating mothers ( SARS-CoV-2 antibodies remain present up to 5 months (143 days) in human milk after onset of COVID-19 symptoms. Overall, SARS-CoV-2 IgA in human milk seems to gradually decrease over time. Human milk from SARS-CoV-2 convalescent lactating mothers contains specific IgA antibodies against SARS-CoV-2 spike protein up to at least 5 months post-infection. Passive viral immunity can be transferred via human milk and may serve as protection for infants against COVID-19.
Sections du résumé
BACKGROUND
Human milk contains antibodies against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) following Coronavirus Disease 2019 (COVID-19). These antibodies may serve as protection against COVID-19 in infants. However, the evolution of these human milk antibodies over time is unclear.
RESEARCH AIM
To elucidate the evolution of immunoglobulin A (IgA) against SARS-CoV-2 in human milk after a SARS-CoV-2 infection.
METHODS
This longitudinal follow-up study included lactating mothers (
RESULTS
SARS-CoV-2 antibodies remain present up to 5 months (143 days) in human milk after onset of COVID-19 symptoms. Overall, SARS-CoV-2 IgA in human milk seems to gradually decrease over time.
CONCLUSION
Human milk from SARS-CoV-2 convalescent lactating mothers contains specific IgA antibodies against SARS-CoV-2 spike protein up to at least 5 months post-infection. Passive viral immunity can be transferred via human milk and may serve as protection for infants against COVID-19.
Identifiants
pubmed: 34308720
doi: 10.1177/08903344211030171
doi:
Substances chimiques
Antibodies, Viral
0
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng