A comprehensive analysis of SNPs and CNVs identifies novel markers associated with disease outcomes in colorectal cancer.
colorectal cancer
genetic variants
genome-wide association study
prognostic markers
proportional hazards (PH) assumption
variables with time-varying associations
Journal
Molecular oncology
ISSN: 1878-0261
Titre abrégé: Mol Oncol
Pays: United States
ID NLM: 101308230
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
29
05
2021
received:
25
03
2021
accepted:
24
07
2021
pubmed:
27
7
2021
medline:
8
4
2022
entrez:
26
7
2021
Statut:
ppublish
Résumé
We aimed to examine the associations of a genome-wide set of single nucleotide polymorphisms (SNPs) and 254 copy number variations (CNVs) and/or insertion/deletions (INDELs) with clinical outcomes in colorectal cancer patients (n = 505). We also aimed to investigate whether their associations changed (e.g., appeared, diminished) over time. Multivariable Cox proportional hazards and piece-wise Cox regression models were used to examine the associations. The Cancer Genome Atlas (TCGA) datasets were used for replication purposes and to examine the gene expression differences between tumor and nontumor tissue samples. A common SNP (WBP11-rs7314075) was associated with disease-specific survival with P-value of 3.2 × 10
Identifiants
pubmed: 34309201
doi: 10.1002/1878-0261.13067
pmc: PMC8637572
doi:
Substances chimiques
DNA-Binding Proteins
0
RNA Splicing Factors
0
WBP11 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3329-3347Informations de copyright
© 2021 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
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