Investigation on the Anticonvulsant Potential of Luteolin and Micronized Luteolin in Adult Zebrafish (Danio rerio).

Age Factors Animals Anticonvulsants / administration & dosage Dose-Response Relationship, Drug Female Luteolin / administration & dosage Male Particle Size Pentylenetetrazole / toxicity Seizures / chemically induced Zebrafish
Epilepsy Luteolin Micronization Seizure Zebrafish

Journal

Neurochemical research
ISSN: 1573-6903
Titre abrégé: Neurochem Res
Pays: United States
ID NLM: 7613461

Informations de publication

Date de publication:
Nov 2021
Historique:
received: 29 03 2021
accepted: 21 07 2021
revised: 09 07 2021
pubmed: 27 7 2021
medline: 5 2 2022
entrez: 26 7 2021
Statut: ppublish

Résumé

Epilepsy affects around 50 million people worldwide, and an important number of patients (30%) fail to respond to any available antiepileptic drug. Previous studies have shown that luteolin presents a promising potential as an anticonvulsant. On the other hand, different studies showed that luteolin does not promote anticonvulsant effects. Therefore, there is a lack of consensus about the use of luteolin for seizure control. Luteolin low bioavailability could be a limiting factor to obtain better results. Attractively, micronization technology has been applied to improve flavonoids bioavailability. Thus, the present study aimed to investigate the effects of luteolin on its raw form and micronized luteolin in a PTZ-induced seizure model in adult zebrafish (Danio rerio). Our results demonstrate that luteolin and micronized luteolin did not block PTZ-induced seizures in adult zebrafish. Also, luteolin and micronized luteolin did not provoke behavioral changes. Finally, our results show that 24 h after seizure occurrence, no changes were detected for p70S6Kb, interleukin 1β, and caspase-3 transcript levels. Altogether, we failed to observe an anticonvulsant potential of luteolin in adult zebrafish, even in its micronized form. However, we recommend new studies to investigate luteolin benefits in epilepsy.

Identifiants

DOI: 10.1007/s11064-021-03409-8 PMID: 34309774
pubmed: 34309774
doi: 10.1007/s11064-021-03409-8
pii: 10.1007/s11064-021-03409-8
doi:

Substances chimiques

Anticonvulsants 0
Luteolin KUX1ZNC9J2
Pentylenetetrazole WM5Z385K7T

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3025-3034

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Auteurs

Cristiane Garbinato (C)

Programa de Pós-Graduação em Ciências Ambientais, Universidade Comunitária da Região de Chapecó, Chapecó, SC, Brazil.

Cássia Alves Lima-Rezende (CA)

Programa de Pós-Graduação em Ciências Ambientais, Universidade Comunitária da Região de Chapecó, Chapecó, SC, Brazil.
División Ornitología, Museo Argentino de Ciencias Naturales, Buenos Aires, Argentina.

Sabrina Ester Schneider (SE)

Curso de Ciências Biológicas, Universidade Comunitária da Região de Chapecó, Chapecó, SC, Brazil.

Jefferson Pedroso (J)

Curso de Ciências Biológicas, Universidade Comunitária da Região de Chapecó, Chapecó, SC, Brazil.

Aline E Dos Santos (AE)

Departamento de Engenharia Química e de Alimentos, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.

Fernanda Petry (F)

Programa de Pós-Graduação em Ciências Ambientais, Universidade Comunitária da Região de Chapecó, Chapecó, SC, Brazil.

Gean Pablo S Aguiar (GPS)

Programa de Pós-Graduação em Ciências Ambientais, Universidade Comunitária da Região de Chapecó, Chapecó, SC, Brazil.

Liz Girardi Müller (LG)

Programa de Pós-Graduação em Ciências Ambientais, Universidade Comunitária da Região de Chapecó, Chapecó, SC, Brazil.

Marcelo Lanza (M)

Departamento de Engenharia Química e de Alimentos, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.

Angelo Piato (A)

Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

J Vladimir Oliveira (J)

Programa de Pós-Graduação em Ciências Ambientais, Universidade Comunitária da Região de Chapecó, Chapecó, SC, Brazil.
Departamento de Engenharia Química e de Alimentos, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.

Anna Maria Siebel (AM)

Programa de Pós-Graduação em Ciências Ambientais, Universidade Comunitária da Região de Chapecó, Chapecó, SC, Brazil. anna.siebel@unochapeco.edu.br.
Curso de Ciências Biológicas, Universidade Comunitária da Região de Chapecó, Chapecó, SC, Brazil. anna.siebel@unochapeco.edu.br.
ORCID: 0000-0002-7896-1456

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs âges › Investigation on the Anticonvulsant Potential...
questionsmedicales.fr › Eucaryotes › Animaux › Investigation on the Anticonvulsant Potential...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Anticonvulsivants › Investigation on the Anticonvulsant Potential...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Investigation on the Anticonvulsant Potential...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Flavones › Lutéoline › Investigation on the Anticonvulsant Potential...
questionsmedicales.fr › Phénomènes chimiques › Taille de particule › Investigation on the Anticonvulsant Potential...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azépines › Pentétrazol › Investigation on the Anticonvulsant Potential...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Crises épileptiques › Investigation on the Anticonvulsant Potential...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Investigation on the Anticonvulsant Potential...