Characterizing plasma NfL in a community-dwelling multi-ethnic cohort: Results from the HABLE study.

Aged Aging Alzheimer Disease / diagnosis Biomarkers Brain Cognitive Dysfunction / diagnosis Humans Independent Living Mexican Americans
Alzheimer's disease Hispanic Mexican American diversity plasma NfL

Journal

Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978

Informations de publication

Date de publication:
02 2022
Historique:
revised: 29 04 2021
received: 04 01 2021
accepted: 02 05 2021
pubmed: 27 7 2021
medline: 26 4 2022
entrez: 26 7 2021
Statut: ppublish

Résumé

No large-scale characterizations of neurofilament light chain (NfL) have been conducted in diverse populations. Baseline data were analyzed among n = 890 Mexican Americans and n = 813 non-Hispanic Whites from the multi-ethnic Health & Aging Brain among Latino Elders (HABLE) study. Plasma NfL was measured on the Simoa platform. In unadjusted models, NfL was significantly associated with age (P < .001), hypertension (P  < .001), dyslipidemia (P = .02), and diabetes (P  < .001). Covarying for age and sex, NfL was associated with neurodegeneration (P  < .001) and global amyloid burden levels (P = .02) in a subset with available data. NfL levels were significantly associated with diagnostic groups (Normal Cognition [NC], mild cognitive impairment [MCI], Dementia; P  < .001); however, there was no cut-score that yielded acceptable diagnostic accuracy. NfL levels produced a sensitivity of 0.60 and specificity of 0.78 with negative predictive value of 89% for detecting amyloid positivity. Plasma NfL levels are significantly impacted by age and medical co-morbidities that are common among older adults, which complicate its utility as a diagnostic biomarker.

Identifiants

DOI: 10.1002/alz.12404 PMID: 34310015 PMC: PMC9228481
pubmed: 34310015
doi: 10.1002/alz.12404
pmc: PMC9228481
mid: NIHMS1779248
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

240-250

Subventions

Organisme : NIA NIH HHS
ID : P30 AG066530
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015922
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054073
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG058533
Pays : United States

Informations de copyright

© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

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Auteurs

Sid O'Bryant (S)

Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.

Melissa Petersen (M)

Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Department of Family Medicine, University of North Texas Health Science Center, Fort Worth, Texas, USA.

James Hall (J)

Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA.

Leigh Johnson (L)

Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA.

Kristine Yaffe (K)

Department of Psychiatry, Neurology, and Epidemiology and Biostatistics, University of California, San Francisco, California, USA.
San Francisco VA Medical Center, San Francisco, California, USA.

Meredith Braskie (M)

Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, USC, Los Angeles, California, USA.

Arthur W Toga (AW)

Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.

Robert A Rissman (RA)

Department of Neurosciences, University of California, San Diego, La Jolla, California, USA.
Veterans Affairs San Diego Healthcare System, San Diego, California, USA.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Characterizing plasma NfL in a...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Characterizing plasma NfL in a...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Characterizing plasma NfL in a...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Characterizing plasma NfL in a...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Characterizing plasma NfL in a...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Characterizing plasma NfL in a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Characterizing plasma NfL in a...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › Caractéristiques de l'habitat › Vie autonome › Characterizing plasma NfL in a...
questionsmedicales.fr › Personnes › Nord-Américains › Groupes de population aux États-Unis › Hispanique ou Latino › Américain origine mexicaine › Characterizing plasma NfL in a...