Mediterranean and Western diet effects on Alzheimer's disease biomarkers, cerebral perfusion, and cognition in mid-life: A randomized trial.
Adult
Aged
Alzheimer Disease
/ cerebrospinal fluid
Amyloid beta-Peptides
/ cerebrospinal fluid
Biomarkers
/ cerebrospinal fluid
Cerebrovascular Circulation
Cognition
/ physiology
Cognitive Dysfunction
/ cerebrospinal fluid
Diet, Mediterranean
Diet, Western
Humans
Middle Aged
Peptide Fragments
/ cerebrospinal fluid
tau Proteins
/ cerebrospinal fluid
Alzheimer's disease
cerebral perfusion
cerebrospinal fluid biomarkers
diet intervention
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
revised:
03
06
2021
received:
07
12
2020
accepted:
11
06
2021
pubmed:
27
7
2021
medline:
26
4
2022
entrez:
26
7
2021
Statut:
ppublish
Résumé
Mid-life dietary patterns are associated with Alzheimer's disease (AD) risk, although few controlled trials have been conducted. Eighty-seven participants (age range: 45 to 65) with normal cognition (NC, n = 56) or mild cognitive impairment (MCI, n = 31) received isocaloric diets high or low in saturated fat, glycemic index, and sodium (Western-like/West-diet vs. Mediterranean-like/Med-diet) for 4 weeks. Diet effects on cerebrospinal fluid (CSF) biomarkers, cognition, and cerebral perfusion were assessed to determine whether responses differed by cognitive status. CSF amyloid beta (Aβ) Diet response during middle age may highlight early pathophysiological processes that increase AD risk.
Identifiants
pubmed: 34310044
doi: 10.1002/alz.12421
pmc: PMC9207984
mid: NIHMS1716856
doi:
Substances chimiques
Amyloid beta-Peptides
0
Biomarkers
0
Peptide Fragments
0
tau Proteins
0
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
457-468Subventions
Organisme : NIA NIH HHS
ID : L30 AG074138
Pays : United States
Organisme : NIH HHS
ID : R37 AG-10880
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG010880
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG033534
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG049638
Pays : United States
Organisme : NINDS NIH HHS
ID : P50 NS062684
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072947
Pays : United States
Informations de copyright
© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
Références
JAMA Neurol. 2019 Aug 01;76(8):915-924
pubmed: 31157827
Alzheimers Res Ther. 2019 Oct 18;11(1):86
pubmed: 31627745
Arch Neurol. 2011 Jun;68(6):743-52
pubmed: 21670398
Nat Rev Neurosci. 2004 May;5(5):347-60
pubmed: 15100718
J Alzheimers Dis. 2014;42 Suppl 4:S411-9
pubmed: 25159672
Neurobiol Aging. 2019 Apr;76:45-52
pubmed: 30682676
Nat Cell Biol. 2001 Oct;3(10):905-12
pubmed: 11584272
Front Aging Neurosci. 2017 Jun 08;9:181
pubmed: 28642699
Arch Neurol. 2003 Feb;60(2):194-200
pubmed: 12580703
J Magn Reson Imaging. 2005 Dec;22(6):727-31
pubmed: 16261572
J Alzheimers Dis. 2017;59(3):815-849
pubmed: 28697569
J Magn Reson Imaging. 2009 May;29(5):1134-9
pubmed: 19388118
Ann Neurol. 2017 Nov;82(5):706-718
pubmed: 29023983
Alzheimers Dement. 2011 May;7(3):270-9
pubmed: 21514249
Neurology. 2018 May 15;90(20):e1789-e1798
pubmed: 29653991
Am J Clin Nutr. 1990 Feb;51(2):241-7
pubmed: 2305711
Alzheimers Dement (Amst). 2015 Dec 12;2:19-26
pubmed: 27239532
Front Physiol. 2017 Oct 30;8:841
pubmed: 29163190
Neurobiol Aging. 2017 Dec;60:192-202
pubmed: 28992987
Neuron. 2004 Oct 14;44(2):227-38
pubmed: 15473963
Cell Stem Cell. 2019 Mar 7;24(3):363-375.e9
pubmed: 30686764
Nutr Neurosci. 2021 Oct;24(10):810-834
pubmed: 31684843
Circulation. 2017 May 30;135(22):2178-2195
pubmed: 28559496
J Clin Exp Neuropsychol. 1992 Mar;14(2):253-67
pubmed: 1572948
Adv Nutr. 2019 Nov 1;10(6):1040-1065
pubmed: 31209456
Neuroimage. 2003 Jul;19(3):1233-9
pubmed: 12880848
Biofactors. 2009 May-Jun;35(3):239-48
pubmed: 19472365
Curr Opin Lipidol. 2019 Jun;30(3):224-234
pubmed: 30946049
Cardiovasc Res. 2014 Aug 1;103(3):405-13
pubmed: 24907980
Front Aging Neurosci. 2017 Oct 31;9:345
pubmed: 29163128
Curr Atheroscler Rep. 2001 Nov;3(6):456-61
pubmed: 11602065
Proc Natl Acad Sci U S A. 1998 May 26;95(11):6460-4
pubmed: 9600988
Acta Neuropathol. 2014 Nov;128(5):679-89
pubmed: 25107476
Magn Reson Med. 2010 Sep;64(3):799-810
pubmed: 20578056
Nat Rev Neurosci. 2020 Jan;21(1):21-35
pubmed: 31780819
Alzheimers Dement. 2022 Mar;18(3):457-468
pubmed: 34310044
Nat Rev Neurol. 2020 Jan;16(1):30-42
pubmed: 31827267
Mol Neurodegener. 2019 Apr 12;14(1):15
pubmed: 30975165
Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):499-508
pubmed: 27771511
JAMA Neurol. 2013 Aug;70(8):972-80
pubmed: 23779114
Nat Genet. 2019 Mar;51(3):404-413
pubmed: 30617256
J Neuropathol Exp Neurol. 2009 Mar;68(3):314-25
pubmed: 19225406
J Intern Med. 2018 Dec;284(6):643-663
pubmed: 30051512
J Clin Psychiatry. 1987 Aug;48(8):314-8
pubmed: 3611032
J Neurosci. 2019 May 22;39(21):4179-4192
pubmed: 30886019
Am J Physiol Endocrinol Metab. 2017 Feb 1;312(2):E89-E97
pubmed: 27899343
Biochim Biophys Acta. 2016 May;1862(5):983-91
pubmed: 26657615
Front Endocrinol (Lausanne). 2017 Apr 04;8:60
pubmed: 28421037
J Int Neuropsychol Soc. 2014 Jan;20(1):11-9
pubmed: 24103232
Magn Reson Med. 1998 Sep;40(3):383-96
pubmed: 9727941
J Alzheimers Dis. 2010;20(3):711-22
pubmed: 20413858
Biochim Biophys Acta. 2016 Apr;1862(4):511-517
pubmed: 26769360