FULL-THICKNESS MACULAR HOLE IN AGE-RELATED MACULAR DEGENERATION PATIENTS WITH TWO DISTINCT ENTITIES: A Multicenter Study.
Aged
Aged, 80 and over
Epiretinal Membrane
/ diagnostic imaging
Female
Follow-Up Studies
Humans
Macular Degeneration
/ diagnostic imaging
Male
Middle Aged
Retinal Perforations
/ diagnostic imaging
Retinal Pigment Epithelium
/ diagnostic imaging
Retrospective Studies
Tomography, Optical Coherence
Visual Acuity
/ physiology
Journal
Retina (Philadelphia, Pa.)
ISSN: 1539-2864
Titre abrégé: Retina
Pays: United States
ID NLM: 8309919
Informations de publication
Date de publication:
01 Oct 2021
01 Oct 2021
Historique:
pubmed:
27
7
2021
medline:
25
12
2021
entrez:
26
7
2021
Statut:
ppublish
Résumé
To describe optical coherence tomography characteristics of full-thickness macular holes (FTMHs) in age-related macular degeneration patients. A multicenter, retrospective, observational case series of patients diagnosed with age-related macular degeneration and FTMHs seen between January 1, 2009, and January 3, 2020. Clinical charts and spectral-domain optical coherence tomography images were reviewed. Optical coherence tomography findings included FTMH-inverted trapezoid or hourglass appearance, central macular thickness (CMT), complete retinal pigment epithelium and complete retinal outer retinal atrophy, and presence of pigment epithelium detachment and epiretinal membrane. The mean outcome was the morphologic and functional characterization of different subtypes of FTMHs. A total of 86 eyes of 85 consecutive patients, with mean age of 80.31 ± 8.06 and mean best-corrected visual acuity of 1.17 ± 0.58 logarithm of the minimal angle of resolution. Two different subtypes of FTMHs were identified: tractional and degenerative. Fifty (58%) degenerative FTMHs characterized with inverted trapezoid appearance and 36 (42%) tractional FTMHs characterized with hourglass appearance. Degenerative FTMHs presented with 66% of CMT < 240 µm, 14% of CMT > 320, and 70% of complete retinal outer retinal atrophy, in comparison with 41% of CMT < 240 µm, 42.9% of CMT > 320%, and 20% of complete retinal outer retinal atrophy in the tractional FTMH group (P = 0.002, 0.003, <0.001, respectively). The presence of epiretinal membrane and pigment epithelium detachment where significantly higher in tractional FTMHs (P = 0.02, 0.03, respectively). Degenerative and tractional FTMHs may be two distinct clinical entities. Discerning degenerative from tractional FTMHs is possible by using optical coherence tomography features including shape of the FTMHs, CMT, internal-external ratio of FTMHs, and presence of complete retinal outer retinal atrophy, pigment epithelium detachment, and epiretinal membrane.
Identifiants
pubmed: 34310095
doi: 10.1097/IAE.0000000000003141
pii: 00006982-202110000-00009
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
2066-2072Références
Jonas JB, Cheung CMG, Panda-Jonas S. Updates on the epidemiology of age-related macular degeneration. Asia-pacific J Ophthalmol 2017;6:493–497.
Lim LS, Mitchell P, Seddon JM, et al. Age-related macular degeneration. Lancet 2012;379:1728–1738.
Ezra E. Idiopathic full thickness macular hole: natural history and pathogenesis. Br J Ophthalmol 2001;85:102–108.
Ho AC, Guyer DR, Fine SL. Macular hole. Surv Ophthalmol 1998;42:393–416.
Klein R, Klein BEK, Wang Q, et al. The epidemiology of epiretinal membranes. In: Transactions of the American Ophthalmological Society. Vol 92: American Ophthalmological Society; 1994:403–430.
Duker JS, Kaiser PK, Binder S, et al. The international vitreomacular traction study group classification of vitreomacular adhesion, traction, and macular hole. Ophthalmology 2013;120:2611–2619.
Takezawa M, Toyoda F, Kambara C, et al. Clarifying the mechanism of idiopathic macular hole development in fellow eyes using spectral-domain optical coherence tomography. Clin Ophthalmol 2011;5:101–108.
Rishi P, Kasinathan N, Sahu C. Foveal atrophy and macular hole formation following intravitreal ranibizumab with/without photodynamic therapy for choroidal neovascularization secondary to age-related macular degeneration. Clin Ophthalmol 2011;5:167–170.
Tabandeh H, Smiddy WE, Sullivan PM, et al. Characteristics and outcomes of choroidal neovascularization occurring after macular hole surgery. Retina 2004;24:714–720.
Nowosielska A. Macular hole surgery in the case of wet age-related macular degeneration treated with intravitreal aflibercept. Case Rep Ophthalmol 2019;10:369–373.
Michalewska Z, Nawrocki J. Vitrectomy with the inverted internal limiting membrane flap technique in eyes with full-thickness macular hole and dry age-related macular degeneration. Eur J Ophthalmol 2020. doi: 10.1177/1120672120921376. Epub ahead of print.
doi: 10.1177/1120672120921376
Moisseiev E, Goldstein M, Loewenstein A, et al. Macular hole following intravitreal bevacizumab injection in choroidal neovascularization caused by age-related macular degeneration. Case Rep Ophthalmol 2010;1:36–41.
Clemens CR, Holz FG, Meyer CH. Macular hole formation in the presence of a pigment epithelial detachment after three consecutive intravitreal antivascular endothelial growth factor injections. J Ocul Pharmacol Ther 2010;26:297–299.
Berinstein DM, Hassan TS, Williams GA, et al. Surgical repair of full-thickness idiopathic macular holes associated with significant macular drusen. Ophthalmology 2000;107:2233–2239.
Rao P, Yonekawa Y, Abbey AM, et al. Prevalence and surgical outcomes of macular hole in eyes with age-related macular degeneration. Ophthalmol Retin 2017;1:158–164.
Zhao P, Wang S, Liu N, et al. A Review of surgical outcomes and advances for macular holes. J Ophthalmol 2018;2018. doi: 10.1155/2018/7389412.
doi: 10.1155/2018/7389412
Ferris FL, Davis MD, Clemons TE, et al. A simplified severity scale for age-related macular degeneration: AREDS report no. 18. Arch Ophthalmol 2005;123:1570–1574.
Yun C, Oh J, Hwang SY, et al. Morphologic characteristics of chronic macular hole on optical coherence tomography. Retina 2012;32:2077–2084.
Haouchine B, Massin P, Tadayoni R, et al. Diagnosis of macular pseudoholes and lamellar macular holes by optical coherence tomography. Am J Ophthalmol 2004;138:732–739.
Sadda SR, Guymer R, Holz FG, et al. Consensus definition for atrophy associated with age-related macular degeneration on OCT: classification of atrophy report 3. Ophthalmology 2018;125:537–548.
Pokroy R, Mimouni M, Barayev E, et al. Prognostic value of subretinal hyperreflective material in neovascular age-related macular degeneration treated with bevacizumab. Retina 2018;38:1485–1491.
Adhi M, Duker JS. Optical coherence tomography-current and future applications. Curr Opin Ophthalmol. 2013;24:213–221.
Okamoto T, Shinoda H, Kurihara T, et al. Intraoperative and fluorescein angiographic findings of a secondary macular hole associated with age-related macular degeneration treated by pars plana vitrectomy. BMC Ophthalmol 2014;14:1–4.
Kabanarou SA, Xirou T, Mangouritsas G, et al. Full-thickness macular hole formation following anti-vegf injections for neovascular age-related macular degeneration. Clin Interv Aging 2017;12:911–915.
Querques G, Souied EH, Soubrane G. Macular hole following intravitreal ranibizumab injection for choroidal neovascular membrane caused by age-related macular degeneration. Acta Ophthalmol 2009;87:235–237.
Cohen SY, Dubois L, Nghiem-Buffet S, et al. Retinal pseudocysts in age-related geographic atrophy. Am J Ophthalmol 2010;150:211–217.e1.
Parravano M, Giansanti F, Eandi CM, et al. Vitrectomy for idiopathic macular hole. Cochrane Database Syst Rev 2015;2015. doi: 10.1002/14651858.CD009080.pub2.
doi: 10.1002/14651858.CD009080.pub2
Chng SW, Patton N, Ahmed M, et al. The manchester large macular hole study: is it time to reclassify large macular holes? Am J Ophthalmol 2018;195:36–42.
Felfeli T, Mandelcorn ED. Macular hole hydrodissection: surgical technique for the treatment of persistent, chronic, and large macular holes. Retina 2019;39:743–752.
Michalewska Z, Michalewski J, Dulczewska-Cichecka K, et al. Temporal inverted internal limiting membrane flap technique versus classic inverted internal limiting membrane flap technique. Retina 2015;35:1844–1850.