Plasma IL-6 levels in unmedicated, comorbidity free obsessive-compulsive disorder.
Cytokines
drug naïve
immune alterations
interleukin-6
obsessive-compulsive disorder
Journal
International journal of psychiatry in clinical practice
ISSN: 1471-1788
Titre abrégé: Int J Psychiatry Clin Pract
Pays: England
ID NLM: 9709509
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
pubmed:
27
7
2021
medline:
24
12
2021
entrez:
26
7
2021
Statut:
ppublish
Résumé
Obsessive-compulsive disorder (OCD) is increasingly being evaluated for a neuro-immune basis. Interleukin-6 (IL-6) is the most widely studied cytokine with a potential role in altering neurotransmission. The evidence for plasma IL-6 alterations in OCD has yielded mixed results. Psychotropic medications are known to modulate inflammatory processes and cytokine levels. In this study, we recruited unmedicated, co-morbidity-free adult OCD patients ( IL-6 plasma level (ng/ml) in unmedicated OCD patients (1.31 ± 0.67) was significantly greater compared to HC (1.03 ± 0.47) [ This study adds to the existing literature on immune alterations in OCD. Alterations in plasma IL-6 might have implications in the neurotransmitter alterations and stress-response in OCD. The current study results in unmedicated and comorbidity-free OCD patients give us a better understanding of the immune alterations in OCD. Future studies in such a population will probably help in reducing the heterogeneity of findings.
Sections du résumé
BACKGROUND
BACKGROUND
Obsessive-compulsive disorder (OCD) is increasingly being evaluated for a neuro-immune basis. Interleukin-6 (IL-6) is the most widely studied cytokine with a potential role in altering neurotransmission. The evidence for plasma IL-6 alterations in OCD has yielded mixed results. Psychotropic medications are known to modulate inflammatory processes and cytokine levels.
METHODS
METHODS
In this study, we recruited unmedicated, co-morbidity-free adult OCD patients (
RESULTS
RESULTS
IL-6 plasma level (ng/ml) in unmedicated OCD patients (1.31 ± 0.67) was significantly greater compared to HC (1.03 ± 0.47) [
CONCLUSIONS
CONCLUSIONS
This study adds to the existing literature on immune alterations in OCD. Alterations in plasma IL-6 might have implications in the neurotransmitter alterations and stress-response in OCD. The current study results in unmedicated and comorbidity-free OCD patients give us a better understanding of the immune alterations in OCD. Future studies in such a population will probably help in reducing the heterogeneity of findings.
Identifiants
pubmed: 34310262
doi: 10.1080/13651501.2021.1937657
doi:
Substances chimiques
Interleukin-6
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM