The maternal gut microbiome during pregnancy and offspring allergy and asthma.

Animals Dietary Supplements Female Gastrointestinal Microbiome Humans Hypersensitivity / epidemiology Infant, Newborn Pregnancy Probiotics Risk
Gut microbiome allergy asthma fetal immunity

Journal

The Journal of allergy and clinical immunology
ISSN: 1097-6825
Titre abrégé: J Allergy Clin Immunol
Pays: United States
ID NLM: 1275002

Informations de publication

Date de publication:
09 2021
Historique:
received: 15 06 2021
revised: 19 07 2021
accepted: 19 07 2021
pubmed: 27 7 2021
medline: 11 11 2021
entrez: 26 7 2021
Statut: ppublish

Résumé

Environmental exposures during pregnancy that alter both the maternal gut microbiome and the infant's risk of allergic disease and asthma include a traditional farm environment and consumption of unpasteurized cow's milk, antibiotic use, dietary fiber, and psychosocial stress. Multiple mechanisms acting in concert may underpin these associations and prime the infant to acquire immune competence and homeostasis following exposure to the extrauterine environment. Cellular and metabolic products of the maternal gut microbiome can promote the expression of microbial pattern recognition receptors, as well as thymic and bone marrow hematopoiesis relevant to regulatory immunity. At birth, transmission of maternally derived bacteria likely leverages this in utero programming to accelerate postnatal transition from a T

Identifiants

DOI: 10.1016/j.jaci.2021.07.011 PMID: 34310928
pubmed: 34310928
pii: S0091-6749(21)01130-1
doi: 10.1016/j.jaci.2021.07.011
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

669-678

Informations de copyright

Copyright © 2021 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Auteurs

Yuan Gao (Y)

Institute for Physical and Mental Health and Clinical Transformation, Deakin University, Geelong, Australia; Child Health Research Unit, Barwon Health, Geelong, Australia; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Ralph Nanan (R)

Charles Perkins Center, The University of Sydney, Sydney, Australia.

Laurence Macia (L)

Charles Perkins Center, The University of Sydney, Sydney, Australia; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

Jian Tan (J)

Charles Perkins Center, The University of Sydney, Sydney, Australia; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

Luba Sominsky (L)

Institute for Physical and Mental Health and Clinical Transformation, Deakin University, Geelong, Australia; Child Health Research Unit, Barwon Health, Geelong, Australia.

Thomas P Quinn (TP)

Applied Artificial Intelligence Institute, Deakin University, Geelong, Australia.

Martin O'Hely (M)

Institute for Physical and Mental Health and Clinical Transformation, Deakin University, Geelong, Australia; Murdoch Children's Research Institute, Melbourne, Australia.

Anne-Louise Ponsonby (AL)

Murdoch Children's Research Institute, Melbourne, Australia; Florey Institute, Melbourne, Australia; University of Melbourne, Melbourne, Australia; the Centre For Food Allergy Research, Murdoch Children's Research Institute, Parkville.

Mimi L K Tang (MLK)

Murdoch Children's Research Institute, Melbourne, Australia; University of Melbourne, Melbourne, Australia; Royal Children's Hospital, Melbourne, Australia; the Centre For Food Allergy Research, Murdoch Children's Research Institute, Parkville.

Fiona Collier (F)

Institute for Physical and Mental Health and Clinical Transformation, Deakin University, Geelong, Australia.

Deborah H Strickland (DH)

Telethon Institute, Perth, Australia; University of Western Australia, Crawley, Australia.

Poshmaal Dhar (P)

Institute for Physical and Mental Health and Clinical Transformation, Deakin University, Geelong, Australia.

Susanne Brix (S)

Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.

Simon Phipps (S)

QIMR Berghofer Medical Research Institute, Herston, Australia; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, St Lucia, Australia; Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Australia.

Peter D Sly (PD)

Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Australia; Children's Health and Environment Program, Child Health Research Centre, The University of Queensland, St Lucia, Australia.

Sarath Ranganathan (S)

Murdoch Children's Research Institute, Melbourne, Australia; University of Melbourne, Melbourne, Australia; Royal Children's Hospital, Melbourne, Australia.

Jakob Stokholm (J)

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark; Department of Pediatrics, Slagelse Hospital, Slagelse, Denmark.

Karsten Kristiansen (K)

BGI-Shenzhen, Shenzhen, China; China National Genebank, Shenzhen, China; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark.

Lawrence E K Gray (LEK)

Institute for Physical and Mental Health and Clinical Transformation, Deakin University, Geelong, Australia; Child Health Research Unit, Barwon Health, Geelong, Australia. Electronic address: Lawrence.gray@barwonhealth.org.au.

Peter Vuillermin (P)

Institute for Physical and Mental Health and Clinical Transformation, Deakin University, Geelong, Australia; Child Health Research Unit, Barwon Health, Geelong, Australia; the Centre For Food Allergy Research, Murdoch Children's Research Institute, Parkville. Electronic address: peter.vuillermin@deakin.edu.au.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The maternal gut microbiome during pregnancy...
questionsmedicales.fr › Aliments et boissons › Aliments › Compléments alimentaires › The maternal gut microbiome during pregnancy...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › The maternal gut microbiome during pregnancy...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The maternal gut microbiome during pregnancy...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › The maternal gut microbiome during pregnancy...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › The maternal gut microbiome during pregnancy...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › The maternal gut microbiome during pregnancy...
questionsmedicales.fr › Aliments et boissons › Aliments › Compléments alimentaires › Probiotiques › The maternal gut microbiome during pregnancy...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › The maternal gut microbiome during pregnancy...