Aspergillus fumigatus Acetate Utilization Impacts Virulence Traits and Pathogenicity.
Aspergillus fumigatus
acetate assimilation
cell wall
secondary metabolites
transcription factor
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
31 08 2021
31 08 2021
Historique:
pubmed:
28
7
2021
medline:
24
12
2021
entrez:
27
7
2021
Statut:
ppublish
Résumé
Aspergillus fumigatus is a major opportunistic fungal pathogen of immunocompromised and immunocompetent hosts. To successfully establish an infection, A. fumigatus needs to use host carbon sources, such as acetate, present in the body fluids and peripheral tissues. However, utilization of acetate as a carbon source by fungi in the context of infection has not been investigated. This work shows that acetate is metabolized via different pathways in A. fumigatus and that acetate utilization is under the regulatory control of a transcription factor (TF), FacB. A. fumigatus acetate utilization is subject to carbon catabolite repression (CCR), although this is only partially dependent on the TF and main regulator of CCR CreA. The available extracellular carbon source, in this case glucose and acetate, significantly affected A. fumigatus virulence traits such as secondary metabolite secretion and cell wall composition, with the latter having consequences for resistance to oxidative stress, antifungal drugs, and human neutrophil-mediated killing. Furthermore, deletion of
Identifiants
pubmed: 34311583
doi: 10.1128/mBio.01682-21
pmc: PMC8406206
doi:
Substances chimiques
Acetates
0
Fungal Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0168221Subventions
Organisme : Medical Research Council
ID : MR/N006364/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V033417/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R56 AI146096
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
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