Investigation of common risk factors between polycystic ovary syndrome and Alzheimer's disease: a narrative review.
Alzheimer disease
Hyperandrogenism
Insulin resistance
Polycystic ovary syndrome
Review
Journal
Reproductive health
ISSN: 1742-4755
Titre abrégé: Reprod Health
Pays: England
ID NLM: 101224380
Informations de publication
Date de publication:
26 Jul 2021
26 Jul 2021
Historique:
received:
01
04
2021
accepted:
13
07
2021
entrez:
27
7
2021
pubmed:
28
7
2021
medline:
29
7
2021
Statut:
epublish
Résumé
The most common endocrine and metabolic disorders in premenopausal women is polycystic ovary syndrome (PCOS), characterized by hyperandrogenism, chronic anovulation, and/or ultrasound evidence of small ovarian cysts. Obesity and insulin resistance are also the main factors influencing the clinical manifestations of this syndrome. Alzheimer's disease (AD) is the most typical progressive neurodegenerative disorder of the brain, and recent studies suggest a relationship between endocrinal dysregulation and neuronal loss during AD pathology. This study aimed to evaluate the common risk factors for Alzheimer's and PCOS based on previous studies. Knowing the common risk factors and eliminating them may prevent neurodegenerative Alzheimer's disease in the future. In this narrative review, international databases, including Google Scholar, Scopus, PubMed, and the Web of Science, were searched to retrieve the relevant studies. The relevant studies' summaries were categorized to discuss the possible pathways that may explain the association between Alzheimer's and PCOS signs/symptoms and complications. According to our research, the factors involved in Alzheimer's and PCOS disorders may share some common risk factors. In patients with PCOS, increased LH to FSH ratio, decreased vitamin D, insulin resistance, and obesity are some of the most important factors that may increase the risk of Alzheimer's disease. Polycystic ovary syndrome is a disorder of the female reproductive system that can be caused by hormonal disorders. The disease is detected by an ultrasound of the ovaries with small ovarian cysts. Obesity and insulin resistance are among the factors that can affect the clinical symptoms of this disease. Obesity due to high-fat consumption can affect cognitive functions with age. Alzheimer’s is the most common disease associated with disorders in brain cells; a link between hormonal disorders and Alzheimer’s has recently been reported. We conducted a review of reports and articles published in connection with polycystic ovary syndrome and neurodegenerative disorders in reputable scientific databases. Studies have shown that the factors involved in polycystic ovary syndrome and Alzheimer’s disease may indicate that both diseases have common risk factors. It may be linked to the symptoms and/or complications of Alzheimer’s disease and polycystic ovary syndrome. Future preclinical studies are needed to closely examine the mechanisms associated with polycystic ovary syndrome and the association with Alzheimer’s. The novelty of our study is from the fact that the PCOS may be to some extent considered as a cause (exposure) among others of AD’s (outcome) and the association might be confounded by some or all the risk factors assessed in this review. The nature of the method—the narrative review—is relatively subjective (in the determination of which studies to include, the way the studies are analyzed, and the conclusions drawn) and hence may not help mitigate bias.
Sections du résumé
BACKGROUND
BACKGROUND
The most common endocrine and metabolic disorders in premenopausal women is polycystic ovary syndrome (PCOS), characterized by hyperandrogenism, chronic anovulation, and/or ultrasound evidence of small ovarian cysts. Obesity and insulin resistance are also the main factors influencing the clinical manifestations of this syndrome. Alzheimer's disease (AD) is the most typical progressive neurodegenerative disorder of the brain, and recent studies suggest a relationship between endocrinal dysregulation and neuronal loss during AD pathology.
AIM
OBJECTIVE
This study aimed to evaluate the common risk factors for Alzheimer's and PCOS based on previous studies. Knowing the common risk factors and eliminating them may prevent neurodegenerative Alzheimer's disease in the future.
METHOD
METHODS
In this narrative review, international databases, including Google Scholar, Scopus, PubMed, and the Web of Science, were searched to retrieve the relevant studies. The relevant studies' summaries were categorized to discuss the possible pathways that may explain the association between Alzheimer's and PCOS signs/symptoms and complications.
RESULTS
RESULTS
According to our research, the factors involved in Alzheimer's and PCOS disorders may share some common risk factors. In patients with PCOS, increased LH to FSH ratio, decreased vitamin D, insulin resistance, and obesity are some of the most important factors that may increase the risk of Alzheimer's disease.
Polycystic ovary syndrome is a disorder of the female reproductive system that can be caused by hormonal disorders. The disease is detected by an ultrasound of the ovaries with small ovarian cysts. Obesity and insulin resistance are among the factors that can affect the clinical symptoms of this disease. Obesity due to high-fat consumption can affect cognitive functions with age. Alzheimer’s is the most common disease associated with disorders in brain cells; a link between hormonal disorders and Alzheimer’s has recently been reported. We conducted a review of reports and articles published in connection with polycystic ovary syndrome and neurodegenerative disorders in reputable scientific databases. Studies have shown that the factors involved in polycystic ovary syndrome and Alzheimer’s disease may indicate that both diseases have common risk factors. It may be linked to the symptoms and/or complications of Alzheimer’s disease and polycystic ovary syndrome. Future preclinical studies are needed to closely examine the mechanisms associated with polycystic ovary syndrome and the association with Alzheimer’s. The novelty of our study is from the fact that the PCOS may be to some extent considered as a cause (exposure) among others of AD’s (outcome) and the association might be confounded by some or all the risk factors assessed in this review. The nature of the method—the narrative review—is relatively subjective (in the determination of which studies to include, the way the studies are analyzed, and the conclusions drawn) and hence may not help mitigate bias.
Autres résumés
Type: plain-language-summary
(eng)
Polycystic ovary syndrome is a disorder of the female reproductive system that can be caused by hormonal disorders. The disease is detected by an ultrasound of the ovaries with small ovarian cysts. Obesity and insulin resistance are among the factors that can affect the clinical symptoms of this disease. Obesity due to high-fat consumption can affect cognitive functions with age. Alzheimer’s is the most common disease associated with disorders in brain cells; a link between hormonal disorders and Alzheimer’s has recently been reported. We conducted a review of reports and articles published in connection with polycystic ovary syndrome and neurodegenerative disorders in reputable scientific databases. Studies have shown that the factors involved in polycystic ovary syndrome and Alzheimer’s disease may indicate that both diseases have common risk factors. It may be linked to the symptoms and/or complications of Alzheimer’s disease and polycystic ovary syndrome. Future preclinical studies are needed to closely examine the mechanisms associated with polycystic ovary syndrome and the association with Alzheimer’s. The novelty of our study is from the fact that the PCOS may be to some extent considered as a cause (exposure) among others of AD’s (outcome) and the association might be confounded by some or all the risk factors assessed in this review. The nature of the method—the narrative review—is relatively subjective (in the determination of which studies to include, the way the studies are analyzed, and the conclusions drawn) and hence may not help mitigate bias.
Identifiants
pubmed: 34311759
doi: 10.1186/s12978-021-01203-x
pii: 10.1186/s12978-021-01203-x
pmc: PMC8314638
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
156Informations de copyright
© 2021. The Author(s).
Références
Fertil Steril. 2016 Jul;106(1):6-15
pubmed: 27233760
Biochem Soc Trans. 2015 Oct;43(5):1108-11
pubmed: 26517932
J Obstet Gynaecol Res. 2018 Feb;44(2):270-277
pubmed: 29094433
Diabetes Obes Metab. 2006 May;8(3):237-49
pubmed: 16634983
Nat Rev Neurol. 2018 Mar;14(3):127
pubmed: 29377005
Endocr Metab Immune Disord Drug Targets. 2008 Jun;8(2):143-51
pubmed: 18537700
Ther Adv Neurol Disord. 2009 Jan;2(1):31-49
pubmed: 19890493
J Alzheimers Dis. 2015;43(4):1137-48
pubmed: 25159676
Lancet Neurol. 2017 Jun;16(6):465-477
pubmed: 28504110
Horm Behav. 2020 Feb;118:104590
pubmed: 31593698
Lancet Neurol. 2019 Mar;18(3):296-306
pubmed: 30661858
Front Endocrinol (Lausanne). 2015 Mar 25;6:45
pubmed: 25859241
Climacteric. 2014 Dec;17(6):657-9
pubmed: 25203615
CNS Neurosci Ther. 2017 Nov;23(11):855-865
pubmed: 28941188
Nat Commun. 2019 Oct 22;10(1):4799
pubmed: 31641124
Brain. 2007 Apr;130(Pt 4):1159-66
pubmed: 17353226
Int J Mol Sci. 2020 Nov 01;21(21):
pubmed: 33139661
Hum Reprod Open. 2019 Jan 04;2019(1):hoy021
pubmed: 31486807
J Endocrinol. 2020 Sep;246(3):247-263
pubmed: 32590339
Reprod Biol Endocrinol. 2019 Aug 16;17(1):67
pubmed: 31420039
Hum Reprod. 2009 Aug;24(8):2014-22
pubmed: 19403562
Immunol Cell Biol. 2020 Jan;98(1):28-41
pubmed: 31654430
J Endocr Soc. 2018 Feb 26;2(4):310-321
pubmed: 29577107
Curr Opin Endocrinol Diabetes Obes. 2016 Jun;23(3):257-63
pubmed: 26866639
J Clin Endocrinol Metab. 1981 Jul;53(1):58-68
pubmed: 7195404
BMJ. 2009 Feb 05;338:b158
pubmed: 19196745
Rev Assoc Med Bras (1992). 2019 Mar;65(3):375-383
pubmed: 30994836
J Nutr. 2003 Jul;133(7):2244-9
pubmed: 12840187
Nature. 2013 May 9;497(7448):211-6
pubmed: 23636330
J Neuroendocrinol. 2013 Nov;25(11):1039-61
pubmed: 23822747
Acta Endocrinol (Buchar). 2017 Apr-Jun;13(2):237-245
pubmed: 31149181
Fertil Steril. 2010 Apr;93(6):1938-41
pubmed: 19249030
Am Fam Physician. 2016 Dec 1;94(11):884-889
pubmed: 27929271
Clin Med Insights Reprod Health. 2019 Sep 03;13:1179558119871269
pubmed: 31516314
Science. 2009 Nov 13;326(5955):1005-7
pubmed: 19779148
J Alzheimers Dis. 2016 May 11;53(2):419-44
pubmed: 27176073
Exp Gerontol. 2011 Feb-Mar;46(2-3):100-7
pubmed: 20851172
Obstet Gynecol Surv. 2004 Feb;59(2):141-54
pubmed: 14752302
Neuropsychobiology. 2019;77(4):197-205
pubmed: 30605907
Mol Cell Endocrinol. 2014 May 25;389(1-2):13-21
pubmed: 24418360
Clin Chim Acta. 2020 Mar;502:214-221
pubmed: 31733195
Nat Rev Endocrinol. 2015 Jul;11(7):393-405
pubmed: 26007613
Life Sci. 2019 Nov 1;236:116940
pubmed: 31604107
Neurobiol Dis. 2002 Nov;11(2):257-74
pubmed: 12505419
Alzheimers Dement. 2017 Jan;13(1):1-7
pubmed: 27583652
J Steroid Biochem Mol Biol. 2014 Jul;142:99-106
pubmed: 23727128
Sci Rep. 2017 Aug 31;7(1):10272
pubmed: 28860512
Alzheimer Dis Assoc Disord. 2007 Jul-Sep;21(3):265
pubmed: 17804962
Pediatr Endocrinol Diabetes Metab. 2017;23(4):204-208
pubmed: 29574473
Brain Res. 2011 Oct 6;1416:80-104
pubmed: 21890115
J Alzheimers Dis. 2011;26(3):495-505
pubmed: 21694454
J Clin Endocrinol Metab. 2001 Mar;86(3):1175-80
pubmed: 11238505
Ann Intern Med. 1973 Jan;78(1):39-45
pubmed: 4734160
Curr Opin Psychiatry. 2014 Nov;27(6):478-83
pubmed: 25188896
Respir Physiol Neurobiol. 2008 Dec 10;164(1-2):213-21
pubmed: 18599386
Turk J Urol. 2018 Jul;44(4):287-293
pubmed: 29932397
Neurology. 2014 Sep 2;83(10):920-8
pubmed: 25098535
Fertil Steril. 2012 Mar;97(3):786-91
pubmed: 22264851
Sleep Med Clin. 2008 Mar;3(1):37-46
pubmed: 19255602
Neuropsychiatr Dis Treat. 2015 Jan 30;11:243-56
pubmed: 25673992
Behav Neurosci. 2012 Feb;126(1):4-16
pubmed: 22289042
Clin Chim Acta. 2019 Dec;499:142-148
pubmed: 31525346
Paediatr Drugs. 2006;8(5):311-8
pubmed: 17037948
J Ayub Med Coll Abbottabad. 2020 Apr- Jun;32(2):255-258
pubmed: 32584004
Mol Psychiatry. 2014 Jan;19(1):69-75
pubmed: 23089633
Horm Behav. 2015 Nov;76:48-56
pubmed: 26031357
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2017 Oct 30;39(5):699-704
pubmed: 29125115
Mol Brain. 2011 Mar 28;4:13
pubmed: 21443795
Nature. 2011 Mar 24;471(7339):508-12
pubmed: 21346761
Steroids. 2012 Mar 10;77(4):300-5
pubmed: 22178787
Aging Dis. 2017 Feb 1;8(1):17-30
pubmed: 28203479
J Clin Med. 2020 Sep 20;9(9):
pubmed: 32962205
Endocr Dev. 2010;17:11-21
pubmed: 19955752
Am J Clin Nutr. 2008 Sep;88(3):638-44
pubmed: 18779278
Gen Comp Endocrinol. 2018 May 1;260:51-57
pubmed: 29273352
Mayo Clin Proc. 2017 Jun;92(6):978-994
pubmed: 28578785
PLoS One. 2018 Dec 4;13(12):e0204748
pubmed: 30513089
Science. 2013 Oct 18;342(6156):373-7
pubmed: 24136970
J Biomed Sci. 2019 May 9;26(1):33
pubmed: 31072403
Int J Mol Sci. 2020 Jul 07;21(13):
pubmed: 32646017
FASEB J. 2019 Jun;33(6):7375-7386
pubmed: 30866655
Front Neurosci. 2019 Jul 31;13:788
pubmed: 31417349
Reprod Sci. 2021 Aug;28(8):2110-2117
pubmed: 33113105
Int J Endocrinol. 2016;2016:6306410
pubmed: 27579037
Endocr Pract. 2014 Mar;20(3):244-51
pubmed: 24246334
Curr Top Behav Neurosci. 2011;8:1-13
pubmed: 21644052
Best Pract Res Clin Obstet Gynaecol. 2004 Oct;18(5):685-706
pubmed: 15380141
Eur J Pharmacol. 2013 Nov 5;719(1-3):170-179
pubmed: 24070815
Biotech Histochem. 2001 Mar;76(2):97-106
pubmed: 11440311
J Clin Invest. 2006 Jul;116(7):1761-6
pubmed: 16823473
J Alzheimers Dis. 2008 Apr;13(3):267-74
pubmed: 18430994
Int J Endocrinol. 2018 Jul 25;2018:1349868
pubmed: 30147722
J Clin Endocrinol Metab. 2000 Aug;85(8):2767-74
pubmed: 10946879
Steroids. 2014 Oct;88:36-43
pubmed: 24945113
Hum Reprod Update. 2009 Jul-Aug;15(4):477-88
pubmed: 19279045
Pharm Res. 2017 Dec;34(12):2614-2627
pubmed: 28589443
Neurosci Biobehav Rev. 2017 Apr;75:257-273
pubmed: 28179129
Drugs. 2008;68(13):1771-85
pubmed: 18729532
Oxid Med Cell Longev. 2020 Nov 30;2020:2638130
pubmed: 33312335
J Assist Reprod Genet. 2018 Jun;35(6):1123-1129
pubmed: 29564739
Int J Geriatr Psychiatry. 2016 Aug;31(8):905-11
pubmed: 26680599
Int J Mol Sci. 2021 Jan 07;22(2):
pubmed: 33430419
Am J Obstet Gynecol. 2017 May;216(5):493.e1-493.e13
pubmed: 28104402
Eur J Endocrinol. 2019 Apr;180(4):265-272
pubmed: 30763274
J Ovarian Res. 2020 Jun 17;13(1):73
pubmed: 32552864
PLoS One. 2014 Jun 19;9(6):e100421
pubmed: 24945655
Mol Hum Reprod. 2014 Jan;20(1):49-58
pubmed: 23900753
Curr Neurol Neurosci Rep. 2018 Jul 16;18(9):57
pubmed: 30014344
Front Endocrinol (Lausanne). 2018 Sep 24;9:544
pubmed: 30319538
J Alzheimers Dis. 2017;58(4):1003-1016
pubmed: 28527218
Am J Geriatr Pharmacother. 2004 Jun;2(2):119-32
pubmed: 15555488
J Alzheimers Dis. 2012;30(3):545-58
pubmed: 22451324
Drugs. 2017 Jan;77(1):47-65
pubmed: 27988872
Sleep Med Rev. 2018 Aug;40:4-16
pubmed: 28890168
Andrology. 2019 Jan;7(1):110-123
pubmed: 30515996