Macrophages on the margin: choroid plexus immune responses.
blood–cerebrospinal fluid barrier
border-associated macrophages
choroid plexus
neurodevelopmental psychiatric disorders
neuroimmune functions
Journal
Trends in neurosciences
ISSN: 1878-108X
Titre abrégé: Trends Neurosci
Pays: England
ID NLM: 7808616
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
31
03
2021
revised:
29
06
2021
accepted:
01
07
2021
pubmed:
28
7
2021
medline:
9
4
2022
entrez:
27
7
2021
Statut:
ppublish
Résumé
The choroid plexus (ChP), an epithelial bilayer containing a network of mesenchymal, immune, and neuronal cells, forms the blood-cerebrospinal fluid (CSF) barrier (BCSFB). While best recognized for secreting CSF, the ChP is also a hotbed of immune cell activity and can provide circulating peripheral immune cells with passage into the central nervous system (CNS). Here, we review recent studies on ChP immune cells, with a focus on the ontogeny, development, and behaviors of ChP macrophages, the principal resident immune cells of the ChP. We highlight the implications of immune cells for ChP barrier function, CSF cytokines and volume regulation, and their contribution to neurodevelopmental disorders, with possible age-specific features to be elucidated in the future.
Identifiants
pubmed: 34312005
pii: S0166-2236(21)00124-7
doi: 10.1016/j.tins.2021.07.002
pmc: PMC8551004
mid: NIHMS1727768
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
864-875Subventions
Organisme : NICHD NIH HHS
ID : P50 HD105351
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS088566
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL110852
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests J.C. has been an employee of Dyne Therapeutics since April 26, 2021.
Références
Immunity. 2013 Jan 24;38(1):79-91
pubmed: 23273845
Neuron. 2013 Jan 9;77(1):10-8
pubmed: 23312512
Front Immunol. 2021 Mar 05;11:609921
pubmed: 33746939
Am J Pathol. 1996 Jun;148(6):1819-38
pubmed: 8669469
Science. 2014 Oct 3;346(6205):89-93
pubmed: 25147279
Science. 2021 Jul 23;373(6553):
pubmed: 34083447
Neuron. 2019 Jan 16;101(2):207-223.e10
pubmed: 30606613
Elife. 2020 Jun 23;9:
pubmed: 32573436
J Neuroinflammation. 2017 Jul 28;14(1):153
pubmed: 28754163
Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2264-9
pubmed: 23335631
Science. 2016 Feb 26;351(6276):933-9
pubmed: 26822608
Science. 2020 Nov 13;370(6518):856-860
pubmed: 33082293
Brain. 2013 Sep;136(Pt 9):2825-35
pubmed: 23838695
Neuroreport. 2005 Jun 21;16(9):903-7
pubmed: 15931059
Physiol Rev. 2012 Oct;92(4):1577-617
pubmed: 23073627
Int J Dev Neurosci. 2018 Dec;71:34-45
pubmed: 30110650
Am J Pathol. 2008 Oct;173(4):1013-28
pubmed: 18787102
Trends Immunol. 2016 Mar;37(3):181-192
pubmed: 26877243
Immunity. 2019 Jan 15;50(1):253-271.e6
pubmed: 30471926
J Neurosci. 2020 Dec 2;40(49):9386-9400
pubmed: 33127853
Nat Neurosci. 2017 Oct;20(10):1371-1376
pubmed: 28846081
Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11388-E11396
pubmed: 30413620
J Neurosci. 2013 Mar 6;33(10):4216-33
pubmed: 23467340
Nat Immunol. 2016 Jul;17(7):797-805
pubmed: 27135602
Mol Psychiatry. 2021 May;26(5):1535-1550
pubmed: 31740755
Front Cell Neurosci. 2015 Mar 12;9:80
pubmed: 25814932
Brain. 2013 Nov;136(Pt 11):3427-40
pubmed: 24088808
Acta Neuropathol. 2018 Mar;135(3):337-361
pubmed: 29368213
Cell Tissue Res. 1999 May;296(2):259-69
pubmed: 10382270
Nat Immunol. 2009 May;10(5):514-23
pubmed: 19305396
Nat Med. 2017 Aug;23(8):997-1003
pubmed: 28692063
Nat Immunol. 2017 Feb;18(2):123-131
pubmed: 28092374
J Neurosci. 2007 Oct 3;27(40):10695-702
pubmed: 17913903
J Mol Med (Berl). 2017 Nov;95(11):1143-1152
pubmed: 28782084
Nature. 2016 Feb 18;530(7590):349-53
pubmed: 26863192
Brain Behav Immun. 2012 May;26(4):607-16
pubmed: 22310922
Front Immunol. 2018 May 16;9:1066
pubmed: 29868025
Nature. 2014 Jan 9;505(7482):223-8
pubmed: 24317693
Science. 2020 Jul 31;369(6503):530-537
pubmed: 32732419
Brain Behav Immun. 2019 Jul;79:216-227
pubmed: 30822467
Vasc Biol. 2020 Mar 20;2(1):H1-H18
pubmed: 32923970
Annu Rev Immunol. 2021 Apr 26;39:251-277
pubmed: 33556248
Nature. 2018 Mar 22;555(7697):524-528
pubmed: 29539641
Nat Commun. 2020 Jan 14;11(1):247
pubmed: 31937773
PLoS Pathog. 2020 May 1;16(5):e1008204
pubmed: 32357162
Brain Behav Immun. 2013 Nov;34:11-6
pubmed: 23597431
Curr Opin Neurobiol. 2010 Oct;20(5):595-600
pubmed: 20705452
Cell Stem Cell. 2020 Dec 3;27(6):937-950.e9
pubmed: 33010822
Ann Neurol. 2019 Dec;86(6):885-898
pubmed: 31591744
Am J Physiol Cell Physiol. 2017 Jun 1;312(6):C673-C686
pubmed: 28330845
Science. 2010 Nov 5;330(6005):841-5
pubmed: 20966214
Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8389-94
pubmed: 12829791
Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Jul;5(7):651-659
pubmed: 32457022
J Autoimmun. 2018 Jul;91:34-44
pubmed: 29627289
Dev Cell. 2020 Feb 10;52(3):261-275
pubmed: 32049038
Science. 2019 Jan 25;363(6425):
pubmed: 30679343
Acta Neuropathol. 2017 Dec;134(6):851-868
pubmed: 28762187
J Neurodev Disord. 2018 Dec 13;10(1):39
pubmed: 30541429
Cell. 2020 Apr 30;181(3):557-573.e18
pubmed: 32259484
Nat Rev Neurol. 2014 Nov;10(11):643-60
pubmed: 25311587
J Neuroinflammation. 2011 May 18;8:51
pubmed: 21592385
Nature. 2016 Feb 11;530(7589):177-83
pubmed: 26814963
Transl Psychiatry. 2016 Nov 29;6(11):e964
pubmed: 27898074
Science. 2016 Aug 19;353(6301):772-7
pubmed: 27540164
Nat Commun. 2015 Aug 18;6:7967
pubmed: 26284939
Nat Commun. 2021 Mar 8;12(1):1503
pubmed: 33686071
J Neurosci. 2015 Apr 22;35(16):6381-93
pubmed: 25904790
J Neurosci. 2020 May 6;40(19):3849-3861
pubmed: 32269105
Lancet Neurol. 2020 Nov;19(11):919-929
pubmed: 33031735
Microsc Res Tech. 1998 Apr 1;41(1):43-56
pubmed: 9550136
Nat Rev Immunol. 2018 Apr;18(4):225-242
pubmed: 29151590
Ann Neurol. 2005 Jan;57(1):67-81
pubmed: 15546155
Biol Psychiatry. 2017 Aug 1;82(3):186-193
pubmed: 28392081
Immunity. 2018 Feb 20;48(2):380-395.e6
pubmed: 29426702
Physiol Rev. 2013 Oct;93(4):1847-92
pubmed: 24137023
J Neurosci. 2015 Mar 25;35(12):4903-16
pubmed: 25810521
Immunity. 2013 Mar 21;38(3):555-69
pubmed: 23477737
Trends Neurosci. 2020 Jul;43(7):458-466
pubmed: 32423764
Br J Psychiatry. 2006 Jun;188:510-8
pubmed: 16738340
EMBO J. 2014 Jan 7;33(1):7-22
pubmed: 24357543
Annu Rev Immunol. 2020 Apr 26;38:597-620
pubmed: 32340575
J Physiol. 2018 Dec;596(23):5723-5756
pubmed: 29774535
Eur J Neurosci. 2007 Jun;25(11):3319-31
pubmed: 17553000
Acta Neuropathol Commun. 2020 Jan 23;8(1):4
pubmed: 31973769
Nat Commun. 2021 Jan 19;12(1):447
pubmed: 33469018
Science. 2016 Aug 19;353(6301):aad8670
pubmed: 27338705
Cell Stem Cell. 2020 Dec 3;27(6):951-961.e5
pubmed: 33113348
Nat Neurosci. 2005 Jun;8(6):752-8
pubmed: 15895084
Lancet Psychiatry. 2018 Nov;5(11):895-904
pubmed: 30270033
Nature. 2020 Jan;577(7790):399-404
pubmed: 31915375
Nat Immunol. 2016 Dec;17(12):1397-1406
pubmed: 27776109
Cell. 2017 Mar 9;168(6):1101-1113.e13
pubmed: 28283064
Cell Mol Life Sci. 2021 Mar;78(6):2429-2457
pubmed: 33427948
Development. 2020 Dec 15;147(23):
pubmed: 33323375
Cell. 2021 May 27;184(11):3056-3074.e21
pubmed: 33932339
Nat Immunol. 2017 Mar 22;18(4):385-392
pubmed: 28323268
Nat Rev Neurosci. 2015 Aug;16(8):445-57
pubmed: 26174708
Lancet Neurol. 2020 Sep;19(9):767-783
pubmed: 32622375
Dev Cell. 2020 Dec 7;55(5):617-628.e6
pubmed: 33038331
Nat Neurosci. 2019 Jun;22(6):1021-1035
pubmed: 31061494
Nat Neurosci. 2017 Sep;20(9):1300-1309
pubmed: 28758994
Sci Transl Med. 2020 Sep 30;12(563):
pubmed: 32998967
Sci Signal. 2020 Sep 29;13(651):
pubmed: 32994212
Am J Psychiatry. 2019 Jul 1;176(7):564-572
pubmed: 31164007
J Neuropathol Exp Neurol. 2010 Sep;69(9):896-909
pubmed: 20720507
Am J Psychiatry. 2010 Sep;167(9):1083-91
pubmed: 20516153
Science. 2005 May 27;308(5726):1314-8
pubmed: 15831717
Brain Behav Immun. 2015 Feb;44:148-58
pubmed: 25241021
Nat Neurosci. 2006 Dec;9(12):1512-9
pubmed: 17115040
Neuron. 2020 Nov 25;108(4):623-639.e10
pubmed: 32961128
Annu Rev Cell Dev Biol. 2020 Oct 6;36:441-468
pubmed: 32722920
Nature. 2021 Jul;595(7868):565-571
pubmed: 34153974
J Cereb Blood Flow Metab. 2012 Jan;32(1):93-104
pubmed: 21829211
Nat Rev Neurosci. 2019 Sep;20(9):547-562
pubmed: 31358892
Acta Neuropathol Commun. 2020 Jun 26;8(1):92
pubmed: 32586411
Glia. 2013 Feb;61(2):150-63
pubmed: 23001583
Curr Opin Pharmacol. 2013 Dec;13(6):895-9
pubmed: 24054811