Cuticular hydrocarbons are associated with mating success and insecticide resistance in malaria vectors.


Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
26 07 2021
Historique:
received: 14 01 2021
accepted: 08 07 2021
entrez: 27 7 2021
pubmed: 28 7 2021
medline: 12 11 2021
Statut: epublish

Résumé

Anopheles coluzzii females, important malaria vectors in Africa, mate only once in their lifetime. Mating occurs in aerial swarms with a high male-to-female ratio, where traits underlying male mating success are largely unknown. Here, we investigated whether cuticular hydrocarbons (CHCs) influence mating success in natural mating swarms in Burkina Faso. As insecticides are widely used in this area for malaria control, we also determined whether CHCs affect insecticide resistance levels. We find that mated males have higher CHC abundance than unmated controls, suggesting CHCs could be determinants of mating success. Additionally, mated males have higher insecticide resistance under pyrethroid challenge, and we show a link between resistance intensity and CHC abundance. Taken together, our results suggest that CHC abundance may be subject to sexual selection in addition to selection by insecticide pressure. This has implications for insecticide resistance management, as these traits may be sustained in the population due to their benefits in mating even in the absence of insecticides.

Identifiants

pubmed: 34312484
doi: 10.1038/s42003-021-02434-1
pii: 10.1038/s42003-021-02434-1
pmc: PMC8313523
doi:

Substances chimiques

Hydrocarbons 0
Insecticides 0
Pheromones 0
Pyrethrins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

911

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI104956
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI124165
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States

Informations de copyright

© 2021. The Author(s).

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Auteurs

Kelsey L Adams (KL)

Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Simon P Sawadogo (SP)

Department of Medical Biology and Public Health, Institut de Recherche en Science de la Santé (IRSS), Bobo-Dioulasso, Burkina Faso.

Charles Nignan (C)

Department of Medical Biology and Public Health, Institut de Recherche en Science de la Santé (IRSS), Bobo-Dioulasso, Burkina Faso.

Abdoulaye Niang (A)

Department of Medical Biology and Public Health, Institut de Recherche en Science de la Santé (IRSS), Bobo-Dioulasso, Burkina Faso.

Douglas G Paton (DG)

Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

W Robert Shaw (W)

Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Adam South (A)

Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA.

Jennifer Wang (J)

Harvard Center for Mass Spectrometry, Harvard University, Cambridge, MA, USA.

Maurice A Itoe (MA)

Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Kristine Werling (K)

Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Entomology, Pennsylvania State University, State College, PA, USA.

Roch K Dabiré (RK)

Department of Medical Biology and Public Health, Institut de Recherche en Science de la Santé (IRSS), Bobo-Dioulasso, Burkina Faso.

Abdoulaye Diabaté (A)

Department of Medical Biology and Public Health, Institut de Recherche en Science de la Santé (IRSS), Bobo-Dioulasso, Burkina Faso.

Flaminia Catteruccia (F)

Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA. fcatter@hsph.harvard.edu.

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Classifications MeSH