Primary Extra-Osseous Ewing Sarcoma of the Thyroid: A Case Report and Review of the Literature.
Cyto-histological correlation
Extra-osseous Ewing sarcoma
Molecular analysis
Thyroid gland
Journal
Head and neck pathology
ISSN: 1936-0568
Titre abrégé: Head Neck Pathol
Pays: United States
ID NLM: 101304010
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
02
06
2021
accepted:
14
07
2021
pubmed:
28
7
2021
medline:
15
6
2022
entrez:
27
7
2021
Statut:
ppublish
Résumé
Extra-osseous Ewing sarcoma (ES) is a rare and aggressive malignant tumor found in a variety of organs. Primary ES of the thyroid is exceedingly rare and few cases have been documented to date. We describe the case of a 54-year old woman with a history of breast carcinoma in whom a unique hypermetabolic left thyroid nodule was identified during a follow-up PET-CT scan. An ultrasound examination showed a hypoechogenic nodule of 3.7 cm. A cytological diagnosis of poorly differentiated thyroid carcinoma was made, and a total thyroidectomy was performed. The surgical specimen revealed a poorly differentiated neoplasm composed of medium-sized cells with scant cytoplasm, expressing pancytokeratin, CD99 and NKX2.2 but lacking p63 and p40 expression. Molecular analysis revealed a EWSR1-FLI1 fusion transcript supporting the diagnosis of a primary extra-osseous ES of the thyroid. The patient received adjuvant chemotherapy and has no evidence of recurrent disease.
Identifiants
pubmed: 34312795
doi: 10.1007/s12105-021-01365-x
pii: 10.1007/s12105-021-01365-x
pmc: PMC9187785
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
581-586Informations de copyright
© 2021. The Author(s).
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