Perception of microstimulation frequency in human somatosensory cortex.
brain-computer interfaces
human
intracortical microstimulation
neuroscience
sensory feedback
somatosensory cortex
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
27 07 2021
27 07 2021
Historique:
received:
24
11
2020
accepted:
22
07
2021
pubmed:
28
7
2021
medline:
21
10
2021
entrez:
27
7
2021
Statut:
epublish
Résumé
Microstimulation in the somatosensory cortex can evoke artificial tactile percepts and can be incorporated into bidirectional brain-computer interfaces (BCIs) to restore function after injury or disease. However, little is known about how stimulation parameters themselves affect perception. Here, we stimulated through microelectrode arrays implanted in the somatosensory cortex of two human participants with cervical spinal cord injury and varied the stimulus amplitude, frequency, and train duration. Increasing the amplitude and train duration increased the perceived intensity on all tested electrodes. Surprisingly, we found that increasing the frequency evoked more intense percepts on some electrodes but evoked less-intense percepts on other electrodes. These different frequency-intensity relationships were divided into three groups, which also evoked distinct percept qualities at different stimulus frequencies. Neighboring electrode sites were more likely to belong to the same group. These results support the idea that stimulation frequency directly controls tactile perception and that these different percepts may be related to the organization of somatosensory cortex, which will facilitate principled development of stimulation strategies for bidirectional BCIs.
Identifiants
pubmed: 34313221
doi: 10.7554/eLife.65128
pii: 65128
pmc: PMC8376245
doi:
pii:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : UH3 NS107714
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS108922
Pays : United States
Déclaration de conflit d'intérêts
CH, SF, JW, MB, JC, RG No competing interests declared
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