Impact of radioiodine treatment on acute phase proteins in hyperthyroid cats.
Acute phase reaction
alpha-1-acid glycoprotein
endocrine
serum amyloid A
Journal
Journal of feline medicine and surgery
ISSN: 1532-2750
Titre abrégé: J Feline Med Surg
Pays: England
ID NLM: 100897329
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
pubmed:
28
7
2021
medline:
5
4
2022
entrez:
27
7
2021
Statut:
ppublish
Résumé
The aim of this study was to investigate the impact of radioiodine treatment (RIT) on the acute phase proteins (APPs) serum amyloid A (SAA), alpha-1-acid glycoprotein (AGP) and haptoglobin (Hp) in hyperthyroid cats. Between June 2013 and November 2014, 33 hyperthyroid cats without clinical or laboratory signs of inflammatory or neoplastic disease and a body weight >2.5 kg were enrolled. Immediately before, and 12, 36, 72 h and 6 days after RIT, serum samples were obtained for determination of APP concentrations. Both SAA and AGP concentrations changed significantly after RIT. The concentration of AGP increased gradually after treatment with a maximum concentration at the end of the study period (median baseline 398 μg/ml; median 6 days post-RIT 562 μg/ml [ RIT induced a mild, mainly not clinically relevant acute phase reaction (APR). AGP and SAA were useful APPs to determine RIT-induced APR.
Identifiants
pubmed: 34313486
doi: 10.1177/1098612X211024954
pmc: PMC8961241
doi:
Substances chimiques
Acute-Phase Proteins
0
Iodine Radioisotopes
0
Orosomucoid
0
Serum Amyloid A Protein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
359-365Références
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