Differential expression of microRNAs associated with neurodegenerative diseases and diabetic nephropathy in protein l-isoaspartyl methyltransferase-deficient mice.
brain
diabetic nephropathy
kidney
microRNAs
neurodegenerative diseases
protein l-isoaspartyl methyltransferase
serum-derived exosomes
Journal
Cell biology international
ISSN: 1095-8355
Titre abrégé: Cell Biol Int
Pays: England
ID NLM: 9307129
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
revised:
15
07
2021
received:
10
04
2021
accepted:
24
07
2021
pubmed:
28
7
2021
medline:
17
2
2022
entrez:
27
7
2021
Statut:
ppublish
Résumé
Protein l-isoaspartyl methyltransferase (PIMT/PCMT1), an enzyme repairing isoaspartate residues in peptides and proteins that result from the spontaneous decomposition of normal l-aspartyl and l-asparaginyl residues during aging, has been revealed to be involved in neurodegenerative diseases (NDDs) and diabetes. However, the molecular mechanisms for a putative association of PIMT dysfunction with these diseases have not been clarified. Our study aimed to identify differentially expressed microRNAs (miRNAs) in the brain and kidneys of PIMT-deficient mice and uncover the epigenetic mechanism of PIMT-involved NDDs and diabetic nephropathy (DN). Differentially expressed miRNAs by sequencing underwent target prediction and enrichment analysis in the brain and kidney of PIMT knockout (KO) mice and age-matched wild-type (WT) littermates. Sequence analysis revealed 40 differentially expressed miRNAs in the PIMT KO mouse brain including 25 upregulated miRNAs and 15 downregulated miRNAs. In the PIMT KO mouse kidney, there were 80 differentially expressed miRNAs including 40 upregulated miRNAs and 40 downregulated miRNAs. Enrichment analysis and a systematic literature review of differentially expressed miRNAs indicated the involvement of PIMT deficiency in the pathogenesis in NDDs and DN. Some overlapped differentially expressed miRNAs between the brain and kidney were quantitatively assessed in the brain, kidney, and serum-derived exosomes, respectively. Despite being preliminary, these results may aid in investigating the pathological hallmarks and identify the potential therapeutic targets and biomarkers for PIMT dysfunction-related NDDs and DN.
Substances chimiques
MicroRNAs
0
Protein D-Aspartate-L-Isoaspartate Methyltransferase
EC 2.1.1.77
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2316-2330Subventions
Organisme : Xinglin Scholar Program of Shanghai University of Traditional Chinese Medicine
Organisme : National Natural Science Foundation of China
ID : 81703831
Informations de copyright
© 2021 International Federation for Cell Biology.
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