Interaction between cognitive leisure activity and long-chain polyunsaturated fatty acid intake on global cognitive decline in a Japanese longitudinal cohort study: National Institute for Longevity Sciences-Longitudinal Study of Aging.
NILS-LSA
cognitive leisure activities
long-chain polyunsaturated fatty acids
Journal
BMC geriatrics
ISSN: 1471-2318
Titre abrégé: BMC Geriatr
Pays: England
ID NLM: 100968548
Informations de publication
Date de publication:
27 07 2021
27 07 2021
Historique:
received:
10
03
2021
accepted:
21
06
2021
entrez:
28
7
2021
pubmed:
29
7
2021
medline:
10
8
2021
Statut:
epublish
Résumé
There is a growing interest in the significance of adopting a variety of lifestyle habits for maintaining cognitive function among older adults. A lifestyle that is easy to modify, simple, and less burdensome for older people is ideal. We investigated the longitudinal association between global cognitive decline and cognitive leisure activities (CLAs) combined with long-chain polyunsaturated fatty acids (LCPUFAs) intake. The National Institute for Longevity Sciences-Longitudinal Study of Aging (NILS-LSA) enrolled community-dwelling middle-aged and older men and women who were randomly selected from Obu-City and Higashiura Town, Aichi, Japan. Baseline data (2006-2008), including CLAs and dietary intake, were obtained from 517 participants (aged 60-84 years) with normal cognition. Global cognitive decline, defined as the Mini-Mental State Examination (MMSE) score ≤ 27, was assessed at baseline and four years later. Interaction between CLAs and LCPUFAs on cognitive decline was investigated using a multiple logistic analysis with adjustment for confounders. CLA engagement and LCPUFA intake were divided into high and low groups according to the frequency at which each participant engaged in the activity and the median intake level according to sex, respectively. A significant interaction was detected for the combination of CLA engagement and LCPUFA intake. Logistic regression coefficients revealed significant interactions when participants engaged in more than five CLA varieties. One of the CLAs, art appreciation, produced a significant main effect against cognitive decline and a significant interaction in combination with LCPUFA intake. The major LCPUFAs-docosahexaenoic acid and arachidonic acid-also exhibited a significant interaction. The combination of high LCPUFA intake and high art appreciation frequency yielded a lower adjusted odds ratio for cognitive decline than the combination of low LCPUFA and low art appreciation [0.25 (95 % confidence intervals, 0.11-0.56)]. Preserving cognitive function might be associated with a combination of varied and high-frequency engagement in CLAs combined with high LCPUFA intake.
Sections du résumé
BACKGROUND
There is a growing interest in the significance of adopting a variety of lifestyle habits for maintaining cognitive function among older adults. A lifestyle that is easy to modify, simple, and less burdensome for older people is ideal. We investigated the longitudinal association between global cognitive decline and cognitive leisure activities (CLAs) combined with long-chain polyunsaturated fatty acids (LCPUFAs) intake.
METHODS
The National Institute for Longevity Sciences-Longitudinal Study of Aging (NILS-LSA) enrolled community-dwelling middle-aged and older men and women who were randomly selected from Obu-City and Higashiura Town, Aichi, Japan. Baseline data (2006-2008), including CLAs and dietary intake, were obtained from 517 participants (aged 60-84 years) with normal cognition. Global cognitive decline, defined as the Mini-Mental State Examination (MMSE) score ≤ 27, was assessed at baseline and four years later. Interaction between CLAs and LCPUFAs on cognitive decline was investigated using a multiple logistic analysis with adjustment for confounders. CLA engagement and LCPUFA intake were divided into high and low groups according to the frequency at which each participant engaged in the activity and the median intake level according to sex, respectively.
RESULTS
A significant interaction was detected for the combination of CLA engagement and LCPUFA intake. Logistic regression coefficients revealed significant interactions when participants engaged in more than five CLA varieties. One of the CLAs, art appreciation, produced a significant main effect against cognitive decline and a significant interaction in combination with LCPUFA intake. The major LCPUFAs-docosahexaenoic acid and arachidonic acid-also exhibited a significant interaction. The combination of high LCPUFA intake and high art appreciation frequency yielded a lower adjusted odds ratio for cognitive decline than the combination of low LCPUFA and low art appreciation [0.25 (95 % confidence intervals, 0.11-0.56)].
CONCLUSIONS
Preserving cognitive function might be associated with a combination of varied and high-frequency engagement in CLAs combined with high LCPUFA intake.
Identifiants
pubmed: 34315440
doi: 10.1186/s12877-021-02359-8
pii: 10.1186/s12877-021-02359-8
pmc: PMC8314584
doi:
Substances chimiques
Fatty Acids, Unsaturated
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
443Subventions
Organisme : National Center for Geriatrics and Gerontology
ID : 899-3
Organisme : National Center for Geriatrics and Gerontology
ID : 899-3
Organisme : National Center for Geriatrics and Gerontology
ID : 899-3
Organisme : National Center for Geriatrics and Gerontology
ID : 899-3
Organisme : National Center for Geriatrics and Gerontology
ID : 899-3
Organisme : National Center for Geriatrics and Gerontology
ID : 899-3
Informations de copyright
© 2021. The Author(s).
Références
Prostaglandins Leukot Essent Fatty Acids. 2019 Sep;148:1-8
pubmed: 31492428
Neuroscience. 2006;139(3):991-7
pubmed: 16527422
Alzheimer Dis Assoc Disord. 2009 Jul-Sep;23(3):198-204
pubmed: 19812459
J Alzheimers Dis. 2017;57(1):85-96
pubmed: 28222531
PLoS One. 2007 Nov 21;2(11):e1201
pubmed: 18030335
Curr Psychiatry Rep. 2016 Sep;18(9):85
pubmed: 27481112
J Geriatr Psychiatry Neurol. 2010 Sep;23(3):151-7
pubmed: 20231732
J Neurol Neurosurg Psychiatry. 2015 Dec;86(12):1299-306
pubmed: 26294005
JAMA. 2002 Feb 13;287(6):742-8
pubmed: 11851541
Lancet Neurol. 2017 May;16(5):377-389
pubmed: 28359749
N Engl J Med. 2003 Jun 19;348(25):2508-16
pubmed: 12815136
Biochim Biophys Acta. 1998 Sep 30;1407(3):205-14
pubmed: 9748581
Int Psychogeriatr. 2016 Nov;28(11):1791-1806
pubmed: 27502691
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
J Neuropsychiatry Clin Neurosci. 2011 Spring;23(2):149-54
pubmed: 21677242
Neurobiol Learn Mem. 2007 Oct;88(3):277-94
pubmed: 17714960
Neuroscience. 1998 Jun;84(4):1075-83
pubmed: 9578396
Prostaglandins Leukot Essent Fatty Acids. 2008 Apr-May;78(4-5):293-304
pubmed: 18499418
Lancet. 2015 Jun 6;385(9984):2255-63
pubmed: 25771249
Neuron. 2017 Aug 30;95(5):1197-1207.e3
pubmed: 28823726
Arch Neurol. 2003 May;60(5):753-9
pubmed: 12756140
PLoS One. 2011;6(7):e21852
pubmed: 21755004
J Neurophysiol. 2004 Apr;91(4):1699-705
pubmed: 15010496
J Epidemiol. 2000 Apr;10(1 Suppl):S1-9
pubmed: 10835822
Neurosci Res. 2003 Aug;46(4):453-61
pubmed: 12871767
Mech Ageing Dev. 2015 Sep;150:55-64
pubmed: 26278494
Neurobiol Aging. 2007 Aug;28(8):1179-86
pubmed: 16790296
J Oleo Sci. 2017 Jul 1;66(7):713-721
pubmed: 28626140
BMJ. 2019 Dec 18;367:l6377
pubmed: 31852659
Arch Neurol. 2008 Jul;65(7):963-7
pubmed: 18625866
J Gerontol. 1993 Jan;48(1):P1-11
pubmed: 8418144
Lipids Health Dis. 2011 Aug 13;10:138
pubmed: 21838914
J Epidemiol. 2013;23(3):178-86
pubmed: 23583922
Lipids. 1991 Jun;26(6):421-5
pubmed: 1881238
Neuroscience. 1999;94(1):305-14
pubmed: 10613520
J Psychosom Res. 2016 Dec;91:20-25
pubmed: 27894458
J Oleo Sci. 2015;64(6):633-44
pubmed: 25891115
Inflamm Res. 2019 Jun;68(6):443-458
pubmed: 30927048
J Epidemiol. 2000 Apr;10(1 Suppl):S70-6
pubmed: 10835831
Mech Ageing Dev. 1998 Mar 16;101(1-2):119-28
pubmed: 9593318
Sci Rep. 2020 Jul 31;10(1):12906
pubmed: 32737350
Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1393-8
pubmed: 12538878
Ann Nutr Metab. 2009;55(1-3):56-75
pubmed: 19752536
Neurosci Res. 2014 Nov;88:58-66
pubmed: 25149915
Psychol Aging. 1999 Jun;14(2):245-63
pubmed: 10403712
Lancet. 2000 Apr 15;355(9212):1315-9
pubmed: 10776744
Arch Gen Psychiatry. 2006 May;63(5):530-8
pubmed: 16651510
Alzheimers Res Ther. 2021 Apr 19;13(1):81
pubmed: 33875016
Nat Med. 2017 Jun;23(6):782-787
pubmed: 28481360
Geriatr Gerontol Int. 2019 Jun;19(6):469-482
pubmed: 31020777
Neuroscience. 1997 Nov;81(1):9-16
pubmed: 9300396
J Psychosom Res. 2012 Feb;72(2):159-64
pubmed: 22281459
Psychol Bull. 2005 Nov;131(6):925-971
pubmed: 16351329
Neurology. 2006 Mar 28;66(6):911-3
pubmed: 16291928
Atherosclerosis. 2014 Feb;232(2):384-9
pubmed: 24468152