Prediction of Pregnancy-Induced Changes in Secretory and Total Renal Clearance of Drugs Transported by Organic Anion Transporters.

Biological Transport, Active / physiology Biotransformation / physiology Dose-Response Relationship, Drug Drug Dosage Calculations Female HEK293 Cells Humans Metabolic Clearance Rate Organic Anion Transporters / classification Pharmaceutical Preparations / classification Pharmacokinetics Pregnancy Pregnancy Trimesters / drug effects Renal Elimination / physiology Reproducibility of Results

Journal

Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550

Informations de publication

Date de publication:
10 2021
Historique:
received: 28 05 2021
accepted: 15 07 2021
pubmed: 29 7 2021
medline: 19 3 2022
entrez: 28 7 2021
Statut: ppublish

Résumé

Pregnancy can significantly change the pharmacokinetics of drugs, including those renally secreted by organic anion transporters (OATs). Quantifying these changes in pregnant women is logistically and ethically challenging. Hence, predicting the in vivo plasma renal secretory clearance (CL

Identifiants

DOI: 10.1124/dmd.121.000557 PMID: 34315779 PMC: PMC8626639
pubmed: 34315779
pii: dmd.121.000557
doi: 10.1124/dmd.121.000557
pmc: PMC8626639
doi:

Substances chimiques

Organic Anion Transporters 0
Pharmaceutical Preparations 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

929-937

Subventions

Organisme : NIDA NIH HHS
ID : P01 DA032507
Pays : United States

Informations de copyright

Copyright © 2021 by The American Society for Pharmacology and Experimental Therapeutics.

Déclaration de conflit d'intérêts

The authors have no conflicts of interest to declare.

Références

Clin Pharmacokinet. 2005;44(10):989-1008
pubmed: 16176115
Drug Metab Dispos. 2020 Jun;49(6):470-478
pubmed: 33824168
Nephrol Dial Transplant. 2021 Nov 9;36(11):2008-2017
pubmed: 33313680
Drug Metab Dispos. 2013 Feb;41(2):320-5
pubmed: 22896729
Br J Clin Pharmacol. 2015 Nov;80(5):1042-50
pubmed: 26040405
Tidsskr Nor Laegeforen. 2018 Oct 30;138(17):
pubmed: 30378417
Br J Clin Pharmacol. 2016 Apr;81(4):646-57
pubmed: 26518984
Reprod Sci. 2011 May;18(5):456-62
pubmed: 21079240
Sci Rep. 2019 Jul 4;9(1):9709
pubmed: 31273226
Clin Pharmacol Ther. 2008 Aug;84(2):248-53
pubmed: 18288078
Am J Obstet Gynecol. 2011 Jul;205(1):51.e1-8
pubmed: 21514558
Kidney Int. 2014 Aug;86(2):350-7
pubmed: 24646860
Clin Pharmacol Ther. 2016 Nov;100(5):413-418
pubmed: 27448198
Anticancer Res. 2020 Apr;40(4):1997-2001
pubmed: 32234889
Clin Pharmacokinet. 2017 Nov;56(11):1303-1330
pubmed: 28401479
Drug Metab Dispos. 2013 Feb;41(2):281-90
pubmed: 23223499
Ann Clin Biochem. 2019 Mar;56(2):266-274
pubmed: 30791693
BJOG. 2008 Jan;115(1):109-12
pubmed: 17970797
Clin Pharmacol Ther. 2007 Apr;81(4):547-56
pubmed: 17329990
HIV Med. 2015 Sep;16(8):502-11
pubmed: 25959631
Br J Clin Pharmacol. 2014 Mar;77(3):554-70
pubmed: 23834474
Physiol Rep. 2019 Nov;7(21):e14229
pubmed: 31724834
Clin Pharmacokinet. 1987 Feb;12(2):136-44
pubmed: 3829560
CPT Pharmacometrics Syst Pharmacol. 2012 Sep 26;1:e3
pubmed: 23835883
Int J Clin Pharmacol Ther. 2020 Apr;58(4):198-208
pubmed: 31933473
J Antimicrob Chemother. 1983 Sep;12 Suppl B:29-37
pubmed: 6355048
Annu Rev Pharmacol Toxicol. 2014;54:53-69
pubmed: 24392692
Clin Pharmacol Ther. 2019 Jun;105(6):1462-1470
pubmed: 30565653
Drug Metab Dispos. 1987 Sep-Oct;15(5):618-26
pubmed: 2891477
Bosn J Basic Med Sci. 2017 Feb 21;17(1):54-60
pubmed: 27968707
Int J Obstet Anesth. 2012 Oct;21(4):334-8
pubmed: 22901775
Drug Metab Dispos. 2013 Apr;41(4):801-13
pubmed: 23355638
Am J Obstet Gynecol. 1998 Oct;179(4):846-51
pubmed: 9790357
PLoS One. 2019 Mar 6;14(3):e0211319
pubmed: 30840711
Biomed Res Int. 2014;2014:897216
pubmed: 24672799
Obstet Gynecol. 2018 May;131(5):789-798
pubmed: 29630018
Drug Metab Dispos. 2017 Aug;45(8):920-938
pubmed: 28588050
Pharmaceutics. 2019 Apr 05;11(4):
pubmed: 30959827
Drug Metab Dispos. 2017 Apr;45(4):409-417
pubmed: 28179375
Biopharm Drug Dispos. 2010 Jul;31(5-6):286-97
pubmed: 20549836
Antimicrob Agents Chemother. 2018 Aug 27;62(9):
pubmed: 30012768
Clin J Am Soc Nephrol. 2012 Dec;7(12):2073-80
pubmed: 22879432
Drug Metab Dispos. 2015 Jun;43(6):836-42
pubmed: 25802327
AIDS. 2013 Mar 13;27(5):739-48
pubmed: 23169329
Am J Obstet Gynecol. 2016 Jun;214(6):720.e1-720.e17
pubmed: 26723196
AIDS Rev. 2014 Oct-Dec;16(4):199-212
pubmed: 25350530
Clin Pharmacol Ther. 2016 Nov;100(5):437-440
pubmed: 27509262
Sports Med. 2009;39(4):331-7
pubmed: 19317520
Adv Chronic Kidney Dis. 2013 May;20(3):209-14
pubmed: 23928384
Annu Rev Pharmacol Toxicol. 2013;53:503-29
pubmed: 23140242
Am J Physiol Renal Physiol. 2007 Jan;292(1):F361-72
pubmed: 16885152
Clin Pharmacokinet. 2017 Dec;56(12):1525-1541
pubmed: 28391404

Auteurs

Jinfu Peng (J)

Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (J.P., M.K.L., J.D.U.); Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, China (J.P.).

Mayur K Ladumor (MK)

Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (J.P., M.K.L., J.D.U.); Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, China (J.P.).

Jashvant D Unadkat (JD)

Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (J.P., M.K.L., J.D.U.); Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, China (J.P.) jash@uw.edu.

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Transport biologique › Transport biologique actif › Prediction of Pregnancy-Induced Changes in...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Biotransformation › Prediction of Pregnancy-Induced Changes in...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Prediction of Pregnancy-Induced Changes in...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Calcul des posologies › Prediction of Pregnancy-Induced Changes in...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Prediction of Pregnancy-Induced Changes in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Prediction of Pregnancy-Induced Changes in...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Taux de clairance métabolique › Prediction of Pregnancy-Induced Changes in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Prediction of Pregnancy-Induced Changes in...
questionsmedicales.fr › Préparations pharmaceutiques › Prediction of Pregnancy-Induced Changes in...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Prediction of Pregnancy-Induced Changes in...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Prediction of Pregnancy-Induced Changes in...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Trimestres de grossesse › Prediction of Pregnancy-Induced Changes in...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques des voies urinaires › Élimination rénale › Prediction of Pregnancy-Induced Changes in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Reproductibilité des résultats › Prediction of Pregnancy-Induced Changes in...