The association of atherosclerotic cardiovascular disease and statin use with inflammation and treatment outcomes in tuberculosis.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
27 07 2021
Historique:
received: 12 05 2021
accepted: 06 07 2021
entrez: 28 7 2021
pubmed: 29 7 2021
medline: 9 11 2021
Statut: epublish

Résumé

Tuberculosis (TB) and atherosclerotic cardiovascular disease (ASCVD) have a close epidemiological and pathogenetic overlap. Thus, it becomes essential to understand the relationship between ASCVD and TB outcomes. From our retrospective cohort on drug-susceptible TB patients at the National Taiwan University Hospital, we assessed the association of pre-existing ASCVD (coronary artery disease (CAD) and atherothrombotic stroke (ATS)) with 9-month all-cause and infection-related mortality and the extent of mediation by systemic inflammatory markers. We determined the effect of pre-existing ASCVD on 2-month sputum microbiological status. Among ASCVD patients, we assessed the association of statin use on mortality. Nine-month all-cause mortality was higher in CAD patients with prior acute myocardial infarction (CAD

Identifiants

pubmed: 34315941
doi: 10.1038/s41598-021-94590-x
pii: 10.1038/s41598-021-94590-x
pmc: PMC8316554
doi:

Substances chimiques

Hydroxymethylglutaryl-CoA Reductase Inhibitors 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

15283

Subventions

Organisme : NIAID NIH HHS
ID : K24 AI143447
Pays : United States
Organisme : NIAID NIH HHS
ID : UH3 AI122309
Pays : United States

Informations de copyright

© 2021. The Author(s).

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Auteurs

Vignesh Chidambaram (V)

Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Koch Cancer Research Building, 1550 Orleans St., Room 110, Baltimore, MD, 21287, USA.

Jennie Ruelas Castillo (J)

Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Koch Cancer Research Building, 1550 Orleans St., Room 110, Baltimore, MD, 21287, USA.

Amudha Kumar (A)

Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Justin Wei (J)

Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Koch Cancer Research Building, 1550 Orleans St., Room 110, Baltimore, MD, 21287, USA.

Siqing Wang (S)

Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Koch Cancer Research Building, 1550 Orleans St., Room 110, Baltimore, MD, 21287, USA.

Marie Gilbert Majella (MG)

Department of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.

Akshay Gupte (A)

Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Koch Cancer Research Building, 1550 Orleans St., Room 110, Baltimore, MD, 21287, USA.

Jann-Yuan Wang (JY)

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Petros C Karakousis (PC)

Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Koch Cancer Research Building, 1550 Orleans St., Room 110, Baltimore, MD, 21287, USA. petros@jhmi.edu.
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. petros@jhmi.edu.

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