RNA expression differences in prostate tumors and tumor-adjacent stroma between Black and White Americans.
African ancestry
European ancestry
RNA-seq analysis
prostate cancer
tumor-adjacent stroma
Journal
Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965
Informations de publication
Date de publication:
20 Jul 2021
20 Jul 2021
Historique:
received:
20
05
2021
accepted:
22
06
2021
entrez:
28
7
2021
pubmed:
29
7
2021
medline:
29
7
2021
Statut:
epublish
Résumé
Prostate cancer (PCa) in Black Americans (BA) is diagnosed at an earlier median age and a more advanced stage than PCa in White Americans (WA). Tumor-adjacent stroma (TAS) plays a critical role in tumorigenesis of prostate cancer. We examined RNA expression in both tumor and TAS of BA compared to WA. After evaluating the geographical ancestry of each sample, preliminary analysis of our own RNA-seq data of 7 BA and 7 WA TAS revealed 1706 downregulated and 1844 upregulated genes in BA relative to WA PCa patients (
Identifiants
pubmed: 34316327
doi: 10.18632/oncotarget.28024
pii: 28024
pmc: PMC8310667
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1457-1469Subventions
Organisme : NCI NIH HHS
ID : R01 CA226570
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001414
Pays : United States
Informations de copyright
Copyright: © 2021 Rahmatpanah et al.
Déclaration de conflit d'intérêts
CONFLICTS OF INTEREST Authors have no conflicts of interest to declare.
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