Loxapine in patient with clozapine-resistant psychosis.
antipsychotic agents
clozapine
loxapine
schizophrenia
Journal
The mental health clinician
ISSN: 2168-9709
Titre abrégé: Ment Health Clin
Pays: United States
ID NLM: 101728585
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
25
09
2020
accepted:
21
04
2021
entrez:
28
7
2021
pubmed:
29
7
2021
medline:
29
7
2021
Statut:
epublish
Résumé
Clozapine is recognized as the drug of choice for treatment-refractory schizophrenia, but use may be limited because of strict monitoring requirements and adverse effects including severe neutropenia, seizures, and myocarditis. Loxapine is a first-generation antipsychotic with similarities to clozapine in both structure and receptor binding. This case describes a 57-year-old male with a history of severe paranoid schizophrenia despite treatment with clozapine and other psychotropic agents, who experienced clinical improvement after a cross titration from clozapine to loxapine. Loxapine may be a reasonable alternative in patients with treatment-refractory schizophrenia who do not tolerate or respond to clozapine.
Identifiants
pubmed: 34316424
doi: 10.9740/mhc.2021.07.263
pii: MHC-D-20-00078
pmc: PMC8287867
doi:
Types de publication
Case Reports
Langues
eng
Pagination
263-266Informations de copyright
© 2021 CPNP. The Mental Health Clinician is a publication of the College of Psychiatric and Neurologic Pharmacists.
Déclaration de conflit d'intérêts
Disclosures: The authors have no conflicts of interest to disclose.
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