Frailty in Parkinson's disease: A systematic review and meta-analysis.
Frailty
Parkinson’s disease
Prevalence
Journal
Clinical parkinsonism & related disorders
ISSN: 2590-1125
Titre abrégé: Clin Park Relat Disord
Pays: England
ID NLM: 101761473
Informations de publication
Date de publication:
2021
2021
Historique:
received:
04
03
2021
revised:
29
04
2021
accepted:
19
05
2021
entrez:
28
7
2021
pubmed:
29
7
2021
medline:
29
7
2021
Statut:
epublish
Résumé
Frailty and Parkinson's disease (PD) are common conditions that increase with age. Independently, frailty and PD lead to increased morbidity and mortality for patients. Few studies report on frailty in patients with PD. We performed a systematic review and We searched four electronic databases and grey literature from inception to May 19, 2020, for articles which reported the prevalence, associations and outcomes of frailty in persons with PD. One-thousand and sixty-three citations were identified, of which 127 articles were reviewed. Thirty studies were included. Twenty-eight studies were observational and the settings varied including 25 community and 5 inpatient studies.The most common frailty screening measures were the frailty phenotype and clinical frailty scale. The prevalence of frailty in PD using the FP was 0.38 (0.24-0.55) with I Frailty is common in PD. There is no agreed upon tool for identifying frailty, however, the importance of its identification is apparent given the high prevalence and the association between frailty and adverse outcomes in persons with PD. Future studies are required to guide clinicians in how best to identify and manage frail patients with PD.
Identifiants
pubmed: 34316672
doi: 10.1016/j.prdoa.2021.100095
pii: S2590-1125(21)00007-4
pmc: PMC8299963
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100095Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Aging Clin Exp Res. 2021 Oct;33(10):2839-2847
pubmed: 33590468
Neurology. 2013 May 28;80(22):2055-61
pubmed: 23635961
BMJ. 2017 Sep 20;358:j4208
pubmed: 28931509
BMC Geriatr. 2017 Jan 21;17(1):28
pubmed: 28107813
J Frailty Aging. 2012;1(3):123-7
pubmed: 27093200
Mech Ageing Dev. 2006 May;127(5):494-6
pubmed: 16487992
Can Geriatr J. 2021 Mar 02;24(1):22-25
pubmed: 33680260
J Am Geriatr Soc. 2013 Mar;61(3):327-34
pubmed: 23351064
Parkinsonism Relat Disord. 2008;14(4):334-7
pubmed: 17988926
J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56
pubmed: 11253156
J Am Geriatr Soc. 2012 Mar;60(3):590-2
pubmed: 22409738
Arch Gerontol Geriatr. 2014 Jan-Feb;58(1):80-7
pubmed: 24063869
Eur Radiol. 2019 May;29(5):2659-2668
pubmed: 30523452
Control Clin Trials. 1986 Sep;7(3):177-88
pubmed: 3802833
CMAJ. 2005 Aug 30;173(5):489-95
pubmed: 16129869
Health Rep. 2013 Sep;24(9):10-7
pubmed: 24258362
BMJ Open. 2021 Mar 22;11(3):e047051
pubmed: 33753447
J R Coll Physicians Edinb. 2018 Jun;48(2):103-107
pubmed: 29992197
Front Neurol. 2020 Apr 09;11:215
pubmed: 32328021
Health Rep. 2014 Nov;25(11):10-4
pubmed: 25408491
Gerontology. 2019;65(3):216-228
pubmed: 30199864
Parkinsonism Relat Disord. 2018 Nov;56:58-64
pubmed: 29914840
BMC Geriatr. 2008 Sep 30;8:24
pubmed: 18826625
J Epidemiol Community Health. 2013 Nov 1;67(11):974-8
pubmed: 23963506
Int J Geriatr Psychiatry. 2020 May;35(5):547-552
pubmed: 31994774
Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul;2019:3507-3510
pubmed: 31946634