Rhabdomyolysis in the Setting of Concomitant Use of Tafamidis, Atorvastatin, and Amiodarone.
ALT, alanine aminotransferase
AST, aspartate aminotransferase
ATTR, transthyretin amyloidosis
BCRP, breast cancer receptor protein
CK, creatinine kinase
CYP3A4, cytochrome P-450 3A4 pathway
LFT, liver function test
atherosclerosis
cardiomyopathy
restrictive
Journal
JACC. Case reports
ISSN: 2666-0849
Titre abrégé: JACC Case Rep
Pays: Netherlands
ID NLM: 101757292
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
19
06
2020
revised:
25
08
2020
accepted:
22
09
2020
entrez:
28
7
2021
pubmed:
29
7
2021
medline:
29
7
2021
Statut:
epublish
Résumé
An 85-year-old women with transthyretin cardiac amyloidosis presented with generalized weakness, elevated liver function test levels, and creatinine kinase consistent with rhabdomyolysis 1 week after starting tafamidis. She was already taking atorvastatin and amiodarone, raising the possibility of a drug-drug interaction inhibiting the breakdown and excretion of atorvastatin, causing drug-induced rhabdomyolysis. (
Identifiants
pubmed: 34317174
doi: 10.1016/j.jaccas.2020.09.037
pii: S2666-0849(20)31189-X
pmc: PMC8304530
doi:
Types de publication
Case Reports
Langues
eng
Pagination
2372-2375Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
The Brigham and Women's/Dana Faber Amyloidosis Program is supported by Leslie and Howard Appleby and the Harold Grinspoon Charitable Foundation. Dr. Falk has received consulting fees from Ionis Pharmaceuticals, Alnylam Pharmaceuticals, and Caelum Biosciences; and research funding from GlaxoSmithKline, Akcea, and Pfizer. Dr. Cuddy has received an investigator-initiated research grant from Pfizer. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
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