Repurposing Riociguat for Treatment of Refractory Angina Resulting From Coronary Spasm.
ACh, acetylcholine
ECG, electrocardiogram
LCx, left circumflex artery
acetylcholine testing
coronary artery spasm
drug repurposing
individual treatment trial
microvascular dysfunction
riociguat
sGC, soluble guanylate cyclase
soluble guanylate cyclase
Journal
JACC. Case reports
ISSN: 2666-0849
Titre abrégé: JACC Case Rep
Pays: Netherlands
ID NLM: 101757292
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
05
11
2020
accepted:
13
11
2020
entrez:
28
7
2021
pubmed:
29
7
2021
medline:
29
7
2021
Statut:
epublish
Résumé
Coronary spasm is a frequent cause of angina despite unobstructed coronary arteries, and symptom control with recommended drugs is limited. We report the case of a 77-year-old woman who had refractory angina despite conventional antianginal treatment. Repurposing riociguat, a soluble guanylate cyclase stimulator, resulted in improvement of symptoms and prevention of spasm. (
Identifiants
pubmed: 34317544
doi: 10.1016/j.jaccas.2020.11.043
pii: S2666-0849(20)31462-5
pmc: PMC8311038
doi:
Types de publication
Case Reports
Langues
eng
Pagination
392-396Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
This work was supported by the Berthold-Leibinger-Foundation, Ditzingen, Germany and the Robert-Bosch-Stiftung, Stuttgart, Germany. The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
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