Pulmonary surveillance in pediatric hematopoietic stem cell transplant: A multinational multidisciplinary survey.

Australasia Child Hematopoietic Stem Cell Transplantation / adverse effects Humans Lung Lung Diseases / diagnosis Surveys and Questionnaires
diagnostic screening programs pediatrics respiratory tract diseases stem cell transplantation

Journal

Cancer reports (Hoboken, N.J.)
ISSN: 2573-8348
Titre abrégé: Cancer Rep (Hoboken)
Pays: United States
ID NLM: 101747728

Informations de publication

Date de publication:
05 2022
Historique:
revised: 16 06 2021
received: 23 05 2021
accepted: 29 06 2021
pubmed: 29 7 2021
medline: 25 5 2022
entrez: 28 7 2021
Statut: ppublish

Résumé

Hematopoietic Stem Cell Transplant (HSCT) is an established treatment for malignant and non-malignant conditions and pulmonary disease is a leading cause of late term morbidity and mortality. Accurate and early detection of pulmonary complications is a critical step in improving long term outcomes. Existing guidelines for surveillance of pulmonary complications post-HSCT contain conflicting recommendations. To determine the breadth of current practice in monitoring for pulmonary complications of pediatric HSCT. An institutional review board approved, online, anonymous multiple-choice survey was distributed to HSCT and pulmonary physicians from the United States of America and Australasia using the REDcap platform. The survey was developed by members of the American Thoracic Society Working Group on Complications of Childhood Cancer, and was designed to assess patient management and service design. A total of 40 (34.8%) responses were received. The majority (62.5%) were pulmonologists, and 82.5% were from the United States of America. In all, 67.5% reported having a protocol for monitoring pulmonary complications and 50.0% reported adhering "well" or "very well" to protocols. Pulmonary function tests (PFTs) most commonly involved spirometry and diffusion capacity for carbon monoxide. The frequency of PFTs varied depending on time post-HSCT and presence of complications. In all, 55.0% reported a set threshold for a clinically significant change in PFT. These results illustrate current variation in surveillance for pulmonary complications of pediatric HSCT. The results of this survey will inform development of future guidelines for monitoring of pulmonary complications after pediatric HSCT.

Sections du résumé

BACKGROUND
Hematopoietic Stem Cell Transplant (HSCT) is an established treatment for malignant and non-malignant conditions and pulmonary disease is a leading cause of late term morbidity and mortality. Accurate and early detection of pulmonary complications is a critical step in improving long term outcomes. Existing guidelines for surveillance of pulmonary complications post-HSCT contain conflicting recommendations.
AIM
To determine the breadth of current practice in monitoring for pulmonary complications of pediatric HSCT.
METHODS
An institutional review board approved, online, anonymous multiple-choice survey was distributed to HSCT and pulmonary physicians from the United States of America and Australasia using the REDcap platform. The survey was developed by members of the American Thoracic Society Working Group on Complications of Childhood Cancer, and was designed to assess patient management and service design.
RESULTS
A total of 40 (34.8%) responses were received. The majority (62.5%) were pulmonologists, and 82.5% were from the United States of America. In all, 67.5% reported having a protocol for monitoring pulmonary complications and 50.0% reported adhering "well" or "very well" to protocols. Pulmonary function tests (PFTs) most commonly involved spirometry and diffusion capacity for carbon monoxide. The frequency of PFTs varied depending on time post-HSCT and presence of complications. In all, 55.0% reported a set threshold for a clinically significant change in PFT.
CONCLUSIONS
These results illustrate current variation in surveillance for pulmonary complications of pediatric HSCT. The results of this survey will inform development of future guidelines for monitoring of pulmonary complications after pediatric HSCT.

Identifiants

DOI: 10.1002/cnr2.1501 PMID: 34319008 PMC: PMC9124519
pubmed: 34319008
doi: 10.1002/cnr2.1501
pmc: PMC9124519
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e1501

Informations de copyright

© 2021 The Authors. Cancer Reports published by Wiley Periodicals LLC.

Références

Hematol Oncol Stem Cell Ther. 2017 Dec;10(4):220-227
pubmed: 28641097
Ann Am Thorac Soc. 2021 Mar;18(3):381-394
pubmed: 33058742
J Pediatr Hematol Oncol. 2015 Nov;37(8):e462-7
pubmed: 26334431
Paediatr Respir Rev. 2007 Mar;8(1):46-61
pubmed: 17419978
Biol Blood Marrow Transplant. 2016 May;22(5):782-95
pubmed: 26802323
Bone Marrow Transplant. 2016 Feb;51(2):267-72
pubmed: 26642337
Semin Hematol. 2006 Jan;43(1):42-52
pubmed: 16412788
Bone Marrow Transplant. 2007 Jan;39(2):89-99
pubmed: 17213848
Biol Blood Marrow Transplant. 2013 Sep;19(9):1348-54
pubmed: 23769819
Clin Chest Med. 2017 Jun;38(2):249-262
pubmed: 28477637
Respirology. 2019 May;24(5):459-466
pubmed: 30663178
Cancer Rep (Hoboken). 2022 May;5(5):e1501
pubmed: 34319008
Biol Blood Marrow Transplant. 2019 Oct;25(10):2024-2030
pubmed: 31201861
Bone Marrow Transplant. 2013 Jun;48(6):814-8
pubmed: 23165500
Biol Blood Marrow Transplant. 2012 Mar;18(3):348-71
pubmed: 22178693
Biol Blood Marrow Transplant. 2016 Mar;22(3):449-55
pubmed: 26541363
Bone Marrow Transplant. 2019 Mar;54(3):383-392
pubmed: 30038355
Eur Respir J. 2018 May 3;51(5):
pubmed: 29650555
JAMA Oncol. 2018 Dec 1;4(12):e182453
pubmed: 30054602
Biol Blood Marrow Transplant. 2014 Mar;20(3):337-44
pubmed: 24315845
Biol Blood Marrow Transplant. 2018 Jun;24(6):1119-1124
pubmed: 29608957
Pediatr Pulmonol. 2019 Jul;54(7):1029-1038
pubmed: 31004401
Pediatr Pulmonol. 2015 Jul;50(7):704-12
pubmed: 24846684
Pediatr Blood Cancer. 2007 Sep;49(3):225-33
pubmed: 17029245
Biol Blood Marrow Transplant. 2018 Jul;24(7):1313-1321
pubmed: 29653206
Respir Med. 2014 Oct;108(10):1525-33
pubmed: 25260979
JAMA. 2009 Jul 15;302(3):306-14
pubmed: 19602690
Biol Blood Marrow Transplant. 2011 Jul;17(7):1072-8
pubmed: 21126596
BMC Pulm Med. 2017 Sep 7;17(1):123
pubmed: 28882120
Biol Blood Marrow Transplant. 2014 Mar;20(3):291-2
pubmed: 24472717
Biol Blood Marrow Transplant. 2007 Jul;13(7):749-59
pubmed: 17580252
Am J Hematol. 2014 Apr;89(4):404-9
pubmed: 24375545
Lancet Respir Med. 2013 Nov;1(9):728-42
pubmed: 24429276

Auteurs

Shivanthan Shanthikumar (S)

Respiratory and Sleep Medicine, Royal Children's Hospital, Parkville, Victoria, Australia.
Respiratory Diseases, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.
ORCID: 0000-0001-6000-3180

William A Gower (WA)

Division of Pediatric Pulmonology, Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina, USA.

Matthew Abts (M)

Seattle Children's Hospital, Seattle, Washington, USA.
Pediatric Pulmonary and Sleep Medicine, University of Washington, Seattle, Washington, USA.

Deborah R Liptzin (DR)

Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.

Elizabeth K Fiorino (EK)

Division of Pulmonology, Allergy, and Immunology, Department of Pediatrics, Weill Cornell Medicine, New York, New York, USA.

Anne Stone (A)

Division of Pulmonology, Department of Pediatrics, Oregon Health & Science University, Portland, Oregon, USA.
ORCID: 0000-0001-6004-4257

Saumini Srinivasan (S)

Division of Pulmonology, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Timothy J Vece (TJ)

Division of Pediatric Pulmonology, Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina, USA.

Nour Akil (N)

Division of Pulmonology, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Theresa Cole (T)

Allergy and Immunology, Royal Children's Hospital, Parkville, Victoria, Australia.

Kenneth R Cooke (KR)

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Samuel B Goldfarb (SB)

Division of Pulmonary and Sleep Medicine, Department of Pediatrics, School of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Régions géographiques › Océanie › Australasie › Pulmonary surveillance in pediatric...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Pulmonary surveillance in pediatric...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches hématopoïétiques › Pulmonary surveillance in pediatric...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pulmonary surveillance in pediatric...
questionsmedicales.fr › Appareil respiratoire › Poumon › Pulmonary surveillance in pediatric...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies pulmonaires › Pulmonary surveillance in pediatric...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Pulmonary surveillance in pediatric...