Agricultural Pesticides and Shingles Risk in a Prospective Cohort of Licensed Pesticide Applicators.
Journal
Environmental health perspectives
ISSN: 1552-9924
Titre abrégé: Environ Health Perspect
Pays: United States
ID NLM: 0330411
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
entrez:
28
7
2021
pubmed:
29
7
2021
medline:
17
3
2022
Statut:
ppublish
Résumé
Some pesticides are immunotoxic and have been associated with an increased risk of immune-mediated diseases. The risk of shingles, the clinical reactivation of varicella-zoster virus, increases with aging and immunosuppression; little is known about its associations with pesticides. We examined the use of agricultural pesticides in relation to incident shingles in a prospective cohort of licensed pesticide applicators. The study sample included 12,820 (97% male) farmers (enrolled in 1993-1997 in North Carolina and Iowa), who were followed for a median of 12 y (interquartile range: 11-13). Shingles was self-reported at enrollment and at follow-up. We evaluated ever-use of 48 agricultural pesticides reported at study enrollment in relation to shingles risk and considered exposure-response for intensity-weighted lifetime days (IWLDs) of use. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazard models, adjusting for state, and allowing estimates to vary by median attained age (60 y). Incident shingles was reported by 590 participants. Associations were positive ( Several specific pesticides were associated with increased risk of shingles in farmers, especially at higher levels of cumulative use. These novel findings, if replicated in other populations, could have broader implications for the potential effects of pesticides on vaccine efficacy and susceptibility to other infections. https://doi.org/10.1289/EHP7797.
Sections du résumé
BACKGROUND
Some pesticides are immunotoxic and have been associated with an increased risk of immune-mediated diseases. The risk of shingles, the clinical reactivation of varicella-zoster virus, increases with aging and immunosuppression; little is known about its associations with pesticides.
OBJECTIVE
We examined the use of agricultural pesticides in relation to incident shingles in a prospective cohort of licensed pesticide applicators.
METHODS
The study sample included 12,820 (97% male) farmers (enrolled in 1993-1997 in North Carolina and Iowa), who were followed for a median of 12 y (interquartile range: 11-13). Shingles was self-reported at enrollment and at follow-up. We evaluated ever-use of 48 agricultural pesticides reported at study enrollment in relation to shingles risk and considered exposure-response for intensity-weighted lifetime days (IWLDs) of use. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazard models, adjusting for state, and allowing estimates to vary by median attained age (60 y).
RESULTS
Incident shingles was reported by 590 participants. Associations were positive (
CONCLUSIONS
Several specific pesticides were associated with increased risk of shingles in farmers, especially at higher levels of cumulative use. These novel findings, if replicated in other populations, could have broader implications for the potential effects of pesticides on vaccine efficacy and susceptibility to other infections. https://doi.org/10.1289/EHP7797.
Identifiants
pubmed: 34319145
doi: 10.1289/EHP7797
pmc: PMC8317610
doi:
Substances chimiques
Pesticides
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
77005Subventions
Organisme : Intramural NIH HHS
ID : Z01 ES049030
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 CP010119
Pays : United States
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