β-Catenin Signaling Regulates the
Animals
DNA Replication
/ genetics
DNA, Viral
/ genetics
Disease Models, Animal
HEK293 Cells
Hepatitis B
/ metabolism
Hepatitis B virus
/ genetics
Hepatocytes
/ virology
Humans
Liver
/ metabolism
Mice
Mice, 129 Strain
Mice, Transgenic
RNA, Viral
/ metabolism
Signal Transduction
/ physiology
Virus Replication
/ genetics
beta Catenin
/ genetics
hepatitis B virus (HBV)
liver lobule
transgenic mice
viral biosynthesis
β-catenin
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
27 09 2021
27 09 2021
Historique:
pubmed:
29
7
2021
medline:
29
3
2022
entrez:
28
7
2021
Statut:
ppublish
Résumé
β-Catenin (Ctnnb1) supports high levels of liver gene expression in hepatocytes in proximity to the central vein functionally defining zone 3 of the liver lobule. This region of the liver lobule supports the highest levels of viral biosynthesis in wild-type hepatitis B virus (HBV) transgenic mice. Liver-specific β-catenin-null HBV transgenic mice exhibit a stark loss of high levels of pericentral viral biosynthesis. Additionally, viral replication that does not depend directly on β-catenin activity appears to expand to include hepatocytes of zone 1 of the liver lobule in proximity to the portal vein, a region of the liver that typically lacks significant HBV biosynthesis in wild-type HBV transgenic mice. While the average amount of viral RNA transcripts does not change, viral DNA replication is reduced approximately 3-fold. Together, these observations demonstrate that β-catenin signaling represents a major determinant of HBV biosynthesis governing the magnitude and distribution of viral replication across the liver lobule
Identifiants
pubmed: 34319157
doi: 10.1128/JVI.00780-21
pmc: PMC8475508
doi:
Substances chimiques
CTNNB1 protein, human
0
DNA, Viral
0
RNA, Viral
0
beta Catenin
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0078021Subventions
Organisme : NIAID NIH HHS
ID : R01 AI125401
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA238328
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002003
Pays : United States
Organisme : HHS | NIH | National Center for Advancing Translational Sciences (NCATS)
ID : UL1TR002003
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