A STAT5B-CD9 axis determines self-renewal in hematopoietic and leukemic stem cells.
Journal
Blood
ISSN: 1528-0020
Titre abrégé: Blood
Pays: United States
ID NLM: 7603509
Informations de publication
Date de publication:
09 12 2021
09 12 2021
Historique:
received:
25
01
2021
accepted:
21
07
2021
pubmed:
29
7
2021
medline:
4
1
2022
entrez:
28
7
2021
Statut:
ppublish
Résumé
The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B are critical in hematopoiesis and leukemia. They are widely believed to have redundant functions, but we describe a unique role for STAT5B in driving the self-renewal of hematopoietic and leukemic stem cells (HSCs/LSCs). We find STAT5B to be specifically activated in HSCs and LSCs, where it induces many genes associated with quiescence and self-renewal, including the surface marker CD9. Levels of CD9 represent a prognostic marker for patients with STAT5-driven leukemia, and our findings suggest that anti-CD9 antibodies may be useful in their treatment to target and eliminate LSCs. We show that it is vital to consider STAT5A and STAT5B as distinct entities in normal and malignant hematopoiesis.
Identifiants
pubmed: 34320169
pii: S0006-4971(21)01406-3
doi: 10.1182/blood.2021010980
pmc: PMC8777465
doi:
Substances chimiques
STAT5 Transcription Factor
0
Tetraspanin 29
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2347-2359Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2021 by The American Society of Hematology.
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