Enantioselective Copper-Catalyzed Synthesis of Trifluoromethyl-Cyclopropylboronates.
Journal
Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393
Informations de publication
Date de publication:
06 08 2021
06 08 2021
Historique:
pubmed:
29
7
2021
medline:
29
7
2021
entrez:
28
7
2021
Statut:
ppublish
Résumé
A copper-catalyzed enantioselective cyclopropanation involving trifluorodiazoethane in the presence of alkenyl boronates has been developed. This transformation enables the preparation of 2-substituted-3-(trifluoromethyl)cyclopropylboronates with high levels of stereocontrol. The products are valuable synthetic intermediates by transformation of the boronate group. This methodology can be applied to the synthesis of novel trifluoromethylated analogues of
Identifiants
pubmed: 34320310
doi: 10.1021/acs.orglett.1c02420
pmc: PMC8895459
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6174-6178Références
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