Immune Signature Linked to COVID-19 Severity: A SARS-Score for Personalized Medicine.
COVID-19
immunologic profile
personalized medicine/personalized health care
score
therapeutic strategy
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
04
2021
accepted:
28
06
2021
entrez:
29
7
2021
pubmed:
30
7
2021
medline:
18
8
2021
Statut:
epublish
Résumé
SARS-CoV-2 infection leads to a highly variable clinical evolution, ranging from asymptomatic to severe disease with acute respiratory distress syndrome, requiring intensive care units (ICU) admission. The optimal management of hospitalized patients has become a worldwide concern and identification of immune biomarkers predictive of the clinical outcome for hospitalized patients remains a major challenge. Immunophenotyping and transcriptomic analysis of hospitalized COVID-19 patients at admission allow identifying the two categories of patients. Inflammation, high neutrophil activation, dysfunctional monocytic response and a strongly impaired adaptive immune response was observed in patients who will experience the more severe form of the disease. This observation was validated in an independent cohort of patients. Using
Identifiants
pubmed: 34322128
doi: 10.3389/fimmu.2021.701273
pmc: PMC8312547
doi:
Substances chimiques
Antiviral Agents
0
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
701273Informations de copyright
Copyright © 2021 Russick, Foy, Josseaume, Meylan, Hamouda, Kirilovsky, Sissy, Tartour, Smadja, Karras, Hulot, Livrozet, Fayol, Arlet, Diehl, Dragon-Durey, Pagès and Cremer.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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