Cancer stem cells, epithelial-mesenchymal transition, ATP and their roles in drug resistance in cancer.
ABC transporters
ATP internalization
Tumor microenvironment
apoptosis
biological markers
macropinocytosis
Journal
Cancer drug resistance (Alhambra, Calif.)
ISSN: 2578-532X
Titre abrégé: Cancer Drug Resist
Pays: United States
ID NLM: 101738710
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
29
7
2021
pubmed:
30
7
2021
medline:
30
7
2021
Statut:
ppublish
Résumé
The cancer stem cell (CSC) state and epithelial-mesenchymal transition (EMT) activation are tightly interconnected. Cancer cells that acquire the EMT/CSC phenotype are equipped with adaptive metabolic changes to maintain low reactive oxygen species levels and stemness, enhanced drug transporters, anti-apoptotic machinery and DNA repair system. Factors present in the tumor microenvironment such as hypoxia and the communication with non-cancer stromal cells also promote cancer cells to enter the EMT/CSC state and display related resistance. ATP, particularly the high levels of intratumoral extracellular ATP functioning through both signaling pathways and ATP internalization, induces and regulates EMT and CSC. The three of them work together to enhance drug resistance. New findings in each of these factors will help us explore deeper into mechanisms of drug resistance and suggest new resistance-associated markers and therapeutic targets.
Identifiants
pubmed: 34322664
doi: 10.20517/cdr.2021.32
pmc: PMC8315560
mid: NIHMS1719283
doi:
Types de publication
Journal Article
Langues
eng
Pagination
684-709Subventions
Organisme : NCI NIH HHS
ID : R15 CA242177
Pays : United States
Déclaration de conflit d'intérêts
Conflicts of interest All authors declared that there are no conflicts of interest.
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