Preoperative detection of the TERT promoter mutations in papillary thyroid carcinomas.
BRAFV600E mutation
TERT promoter mutation
fine-needle aspiration papillary thyroid carcinoma
Journal
Clinical endocrinology
ISSN: 1365-2265
Titre abrégé: Clin Endocrinol (Oxf)
Pays: England
ID NLM: 0346653
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
revised:
05
07
2021
received:
21
05
2021
accepted:
19
07
2021
pubmed:
30
7
2021
medline:
28
10
2021
entrez:
29
7
2021
Statut:
ppublish
Résumé
Telomerase reverse transcriptase promoter (TERT-p) mutations are strongly associated with tumour aggressiveness and worse prognosis in papillary thyroid carcinomas (PTCs). Since the TERT-p mutations have been reported to be subclonal, it is unclear how accurately they can be detected by preoperative fine-needle aspiration (FNA). The objective of this study was to analyse the concordance rate of the TERT-p mutations between preoperative FNA and corresponding postoperative surgical specimens. Ninety-six cases of PTC aged 55 years or older were studied. The mutational status of TERT-p was detected by droplet digital polymerase chain reaction assay. The mutational status of the TERT-p in FNA samples was highly concordant with that in postoperative formalin-fixed and paraffin-embedded (FFPE) specimens. The TERT-p mutation was significantly associated with age, tumour size, extrathyroidal extension and the Ki-67 labelling index in multivariate analysis in both FNA and FFPE samples. The detection of the TERT-p mutations using FNA samples has a good ability to predict disease aggressiveness and, therefore, could be clinically useful in the determination of PTC management.
Substances chimiques
Proto-Oncogene Proteins B-raf
EC 2.7.11.1
TERT protein, human
EC 2.7.7.49
Telomerase
EC 2.7.7.49
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
790-799Subventions
Organisme : Japan Society for the Promotion of Science (JSPS KAKENHI)
ID : 19K09913
Informations de copyright
© 2021 John Wiley & Sons Ltd.
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