Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging.
aging
mouse
neuromuscular junction
regenerative medicine
single cell RNA-seq
stem cells
synapse
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
29 07 2021
29 07 2021
Historique:
received:
21
01
2021
accepted:
28
07
2021
pubmed:
30
7
2021
medline:
13
10
2021
entrez:
29
7
2021
Statut:
epublish
Résumé
During aging and neuromuscular diseases, there is a progressive loss of skeletal muscle volume and function impacting mobility and quality of life. Muscle loss is often associated with denervation and a loss of resident muscle stem cells (satellite cells or MuSCs); however, the relationship between MuSCs and innervation has not been established. Herein, we administered severe neuromuscular trauma to a transgenic murine model that permits MuSC lineage tracing. We show that a subset of MuSCs specifically engraft in a position proximal to the neuromuscular junction (NMJ), the synapse between myofibers and motor neurons, in healthy young adult muscles. In aging and in a mouse model of neuromuscular degeneration (Cu/Zn superoxide dismutase knockout -
Identifiants
pubmed: 34323217
doi: 10.7554/eLife.66749
pii: 66749
pmc: PMC8360658
doi:
pii:
Substances chimiques
Sod1 protein, mouse
EC 1.15.1.1
Superoxide Dismutase-1
EC 1.15.1.1
Banques de données
GEO
['GSE165978', 'GSE147127']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : P30 AG024824
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR071379
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM086262
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG041688
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR069620
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG051442
Pays : United States
Organisme : NIAMS NIH HHS
ID : R61 AR078072
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG051456
Pays : United States
Informations de copyright
© 2021, Larouche et al.
Déclaration de conflit d'intérêts
JL, MM, JC, PU, PF, KS, SP, SK, JC, WL, RH, LB, JM, KD, BL, SM, GV, JC, YJ, SB, CA No competing interests declared
Références
J Gerontol A Biol Sci Med Sci. 2003 Oct;58(10):M911-6
pubmed: 14570858
Neuron. 2014 Jul 16;83(2):331-343
pubmed: 25033179
Aging Cell. 2016 Apr;15(2):361-9
pubmed: 26762731
Elife. 2018 Aug 16;7:
pubmed: 30113308
Neuron. 1995 Jan;14(1):125-32
pubmed: 7826630
Cell. 2000 Mar 3;100(5):525-35
pubmed: 10721990
Dev Cell. 2011 Aug 16;21(2):273-87
pubmed: 21782525
Nat Cell Biol. 2018 Jan;20(1):46-57
pubmed: 29255171
Elife. 2021 Jul 29;10:
pubmed: 34323217
Science. 2002 Aug 30;297(5586):1525-31
pubmed: 12202822
Physiol Rev. 2013 Jan;93(1):23-67
pubmed: 23303905
Free Radic Biol Med. 2021 Mar;165:299-311
pubmed: 33561489
Trends Neurosci. 2012 Jul;35(7):441-53
pubmed: 22633140
Nature. 2018 Aug;560(7719):494-498
pubmed: 30089906
Nat Genet. 2018 Jun;50(6):814-824
pubmed: 29808028
Anat Embryol (Berl). 2005 Apr;209(4):269-79
pubmed: 15761724
Exp Cell Res. 2005 Nov 15;311(1):167-76
pubmed: 16214131
Nat Commun. 2021 Feb 2;12(1):750
pubmed: 33531466
Nat Biotechnol. 2020 Dec;38(12):1408-1414
pubmed: 32747759
Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4359-64
pubmed: 15749817
Development. 2019 Apr 11;146(12):
pubmed: 30890574
Cell Biol Int. 2013 Jul;37(7):731-6
pubmed: 23505055
Histochem Cell Biol. 2005 Jul;124(1):13-23
pubmed: 16001203
Elife. 2017 Jun 06;6:
pubmed: 28583253
FASEB J. 2010 May;24(5):1376-90
pubmed: 20040516
Elife. 2015 Aug 27;4:
pubmed: 26312504
Cell Death Discov. 2018 Feb 20;4:33
pubmed: 29531830
Dev Biol. 2004 Nov 15;275(2):287-300
pubmed: 15501219
Nat Metab. 2019 Oct;1(10):985-995
pubmed: 32021964
Nat Rev Mol Cell Biol. 2011 Dec 21;13(2):127-33
pubmed: 22186952
Nat Med. 2014 Aug;20(8):870-80
pubmed: 25100532
J Neurosci. 2006 May 24;26(21):5739-49
pubmed: 16723531
Genome Biol. 2014;15(12):550
pubmed: 25516281
Nat Biotechnol. 2016 May;34(5):525-7
pubmed: 27043002
Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18812-7
pubmed: 19020093
Mech Ageing Dev. 1982 Dec;20(4):377-83
pubmed: 7166986
Elife. 2018 Oct 15;7:
pubmed: 30320556
Nat Cell Biol. 2017 May;19(5):558-567
pubmed: 28414312
Adv Sci (Weinh). 2020 Dec 21;8(3):2002825
pubmed: 33552865
Annu Rev Neurosci. 1999;22:389-442
pubmed: 10202544
J Cell Physiol. 2004 May;199(2):274-83
pubmed: 15040010
Neuron. 2001 Jul 19;31(1):15-22
pubmed: 11498047
Cell. 2008 Jul 11;134(1):37-47
pubmed: 18614009
J Cell Biol. 2004 Aug 2;166(3):347-57
pubmed: 15277541
Nature. 2020 Jul;583(7817):590-595
pubmed: 32669714
Exp Gerontol. 2011 Feb-Mar;46(2-3):193-8
pubmed: 20854887
Annu Rev Physiol. 2018 Feb 10;80:159-188
pubmed: 29195055
Curr Biol. 2012 Oct 9;22(19):1831-8
pubmed: 22959350
Cell. 2019 Jun 13;177(7):1873-1887.e17
pubmed: 31178122
Nat Med. 2015 Aug;21(8):854-62
pubmed: 26248268
Cell Stem Cell. 2009 Jun 5;4(6):535-47
pubmed: 19497282
Nat Commun. 2020 Dec 11;11(1):6374
pubmed: 33311464
F1000Res. 2015 Dec 30;4:1521
pubmed: 26925227
Nat Neurosci. 2011 May;14(5):570-7
pubmed: 21441923
Nat Biotechnol. 2018 Jun;36(5):411-420
pubmed: 29608179
Cell Rep. 2020 Jul 28;32(4):107964
pubmed: 32726628
Cell Signal. 2004 May;16(5):551-63
pubmed: 14751541
Nat Biotechnol. 2018 Dec 03;:
pubmed: 30531897
iScience. 2020 Mar 27;23(3):100882
pubmed: 32062421
J Orthop Res. 2018 Feb;36(2):632-641
pubmed: 29094772
Neuron. 2016 Dec 7;92(5):1007-1019
pubmed: 27839998
Stem Cell Reports. 2016 Nov 8;7(5):983-997
pubmed: 27773702
J Neurosci. 2011 Oct 19;31(42):14910-9
pubmed: 22016524
J Cell Biochem. 2011 Aug;112(8):2149-59
pubmed: 21465538
Nat Commun. 2020 Sep 9;11(1):4510
pubmed: 32908143
World J Biol Chem. 2013 Feb 26;4(1):1-12
pubmed: 23580916
Curr Opin Neurobiol. 2011 Feb;21(1):151-9
pubmed: 21239163
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Mol Cell. 2019 May 2;74(3):521-533.e6
pubmed: 30952514
Development. 2020 May 5;147(9):
pubmed: 32198156
Cell. 2019 Jun 13;177(7):1888-1902.e21
pubmed: 31178118
J Neurosci. 2008 Sep 24;28(39):9599-609
pubmed: 18815246
J Neurosci. 2016 Sep 21;36(38):9770-81
pubmed: 27656017
Sci Rep. 2014 Nov 13;4:7026
pubmed: 25391618
Nat Methods. 2015 Feb;12(2):115-21
pubmed: 25633503
Nature. 2018 Oct;562(7727):367-372
pubmed: 30283141
Neuron. 2003 Oct 9;40(2):243-64
pubmed: 14556707
FASEB J. 2014 Apr;28(4):1666-81
pubmed: 24378874
Elife. 2020 Jun 25;9:
pubmed: 32584256
Nat Rev Mol Cell Biol. 2016 May;17(5):267-79
pubmed: 26956195
Nat Commun. 2017 Jan 16;8:14049
pubmed: 28091601
Cold Spring Harb Perspect Biol. 2012 Jun;4(6):
pubmed: 22510459
Front Cell Neurosci. 2019 Feb 11;13:33
pubmed: 30804758
Mol Biol Cell. 2009 Aug;20(16):3620-7
pubmed: 19553472
J Peripher Nerv Syst. 2000 Dec;5(4):191-208
pubmed: 11151980
Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2648-53
pubmed: 9122250
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14863-8
pubmed: 20679195
Development. 2017 May 1;144(9):1712-1724
pubmed: 28348167
Skelet Muscle. 2016 Sep 01;6(1):29
pubmed: 27588166