Disrupting cortico-cerebellar communication impairs dexterity.
cerebellum
dexterity
motor cortex
mouse
neural dynamics
neuroscience
pontine nuclei
reaching
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
29 07 2021
29 07 2021
Historique:
received:
18
12
2020
accepted:
28
06
2021
entrez:
29
7
2021
pubmed:
30
7
2021
medline:
13
10
2021
Statut:
epublish
Résumé
To control reaching, the nervous system must generate large changes in muscle activation to drive the limb toward the target, and must also make smaller adjustments for precise and accurate behavior. Motor cortex controls the arm through projections to diverse targets across the central nervous system, but it has been challenging to identify the roles of cortical projections to specific targets. Here, we selectively disrupt cortico-cerebellar communication in the mouse by optogenetically stimulating the pontine nuclei in a cued reaching task. This perturbation did not typically block movement initiation, but degraded the precision, accuracy, duration, or success rate of the movement. Correspondingly, cerebellar and cortical activity during movement were largely preserved, but differences in hand velocity between control and stimulation conditions predicted from neural activity were correlated with observed velocity differences. These results suggest that while the total output of motor cortex drives reaching, the cortico-cerebellar loop makes small adjustments that contribute to the successful execution of this dexterous movement.
Identifiants
pubmed: 34324417
doi: 10.7554/eLife.65906
pii: 65906
pmc: PMC8321550
doi:
pii:
Banques de données
Dryad
['10.5061/dryad.mgqnk990f']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Howard Hughes Medical Institute
Pays : United States
Informations de copyright
© 2021, Guo et al.
Déclaration de conflit d'intérêts
JG, BS, JC, MM, AG, FP, KB, AH No competing interests declared
Références
J Neurophysiol. 1993 Apr;69(4):1136-49
pubmed: 8492153
J Neurophysiol. 1977 Sep;40(5):1038-50
pubmed: 409807
Neuron. 2019 Jul 17;103(2):335-348.e5
pubmed: 31174960
Brain Res. 1972 Feb 25;37(2):173-85
pubmed: 5061111
Nature. 2017 Nov 8;551(7679):232-236
pubmed: 29120427
J Comp Neurol. 1946 Feb;84:31-118
pubmed: 21019911
Elife. 2013 Feb 26;2:e00400
pubmed: 23467508
J Neurophysiol. 1989 Jul;62(1):198-211
pubmed: 2754472
Brain. 2004 Jun;127(Pt 6):1269-91
pubmed: 15128614
Neurosci Res. 1992 Mar;13(2):83-118
pubmed: 1374872
Brain Res. 1975 Aug 29;94(2):237-51
pubmed: 807298
J Neurophysiol. 2000 Apr;83(4):1886-99
pubmed: 10758100
Brain. 1983 Sep;106 (Pt 3):675-705
pubmed: 6640276
Neuron. 2017 Aug 2;95(3):683-696.e11
pubmed: 28735748
J Neurophysiol. 2000 Jul;84(1):585-90
pubmed: 10899231
Brain Res Bull. 1986 Aug;17(2):169-79
pubmed: 2429739
Nat Neurosci. 2016 Apr;19(4):554-6
pubmed: 26950004
Cell Rep. 2018 Feb 27;22(9):2322-2333
pubmed: 29490269
J Comp Neurol. 1989 Aug 22;286(4):427-41
pubmed: 2778100
Neurosci Res. 1987 Dec;5(2):140-56
pubmed: 3431754
Cell Rep. 2020 May 12;31(6):107595
pubmed: 32402292
Cell Rep. 2019 May 28;27(9):2608-2619.e4
pubmed: 31141686
Elife. 2015 Dec 02;4:e10774
pubmed: 26633811
Cell. 2019 Sep 19;179(1):268-281.e13
pubmed: 31495573
Proc Natl Acad Sci U S A. 2011 May 3;108(18):7595-600
pubmed: 21504945
Physiol Rev. 1992 Oct;72(4):967-1017
pubmed: 1438583
Neuroscience. 1988 Apr;25(1):27-45
pubmed: 3393281
Behav Brain Res. 1986 Sep;21(3):167-81
pubmed: 3768133
Cell Rep. 2018 May 1;23(5):1275-1285
pubmed: 29719244
J Neurophysiol. 1998 Feb;79(2):537-54
pubmed: 9463420
J Neurophysiol. 1973 Nov;36(6):974-95
pubmed: 4202614
Nature. 2020 Jan;577(7790):386-391
pubmed: 31875851
Cell. 2019 Apr 18;177(3):669-682.e24
pubmed: 30929904
J Comp Neurol. 2004 Oct 18;478(3):306-22
pubmed: 15368533
Brain. 2001 Mar;124(Pt 3):571-86
pubmed: 11222457
Nat Neurosci. 2014 Oct;17(10):1395-403
pubmed: 25174005
J Neurophysiol. 1974 Jul;37(4):792-804
pubmed: 4209702
J Comp Neurol. 1985 Jul 8;237(2):251-63
pubmed: 4031124
Nat Neurosci. 2018 Sep;21(9):1281-1289
pubmed: 30127430
Brain. 1968 Mar;91(1):1-14
pubmed: 4966862
Brain Res. 1975 Aug 29;94(2):219-36
pubmed: 807297
J Neurosci. 2017 Oct 18;37(42):10085-10096
pubmed: 28916520
Cell Rep. 2018 Mar 6;22(10):2767-2783
pubmed: 29514103
Nature. 2011 Dec 25;481(7382):502-5
pubmed: 22198670
Nature. 2018 Nov;563(7729):113-116
pubmed: 30333626
J Neurosci. 2012 Apr 25;32(17):5990-9
pubmed: 22539859
Nat Neurosci. 2017 Aug;20(8):1180-1188
pubmed: 28628101
J Neurophysiol. 2000 Oct;84(4):1781-9
pubmed: 11024070
Neuron. 2013 Dec 18;80(6):1368-83
pubmed: 24360541
Science. 2019 Apr 19;364(6437):255
pubmed: 31000656
J Neurosci. 2009 May 13;29(19):6154-66
pubmed: 19439593