Role of epidermal growth factor receptor signaling in a Pt(II)-resistant human breast cancer cell line.

Breast Neoplasms / drug therapy Cell Line, Tumor Cell Proliferation / drug effects Dose-Response Relationship, Drug Drug Resistance, Neoplasm / drug effects ErbB Receptors / biosynthesis Female Humans MCF-7 Cells Platinum Compounds / pharmacology Signal Transduction / drug effects
Breast cancer EGFR ERK1/2 PI3K/Akt PKC-δ Src

Journal

Biochemical pharmacology
ISSN: 1873-2968
Titre abrégé: Biochem Pharmacol
Pays: England
ID NLM: 0101032

Informations de publication

Date de publication:
10 2021
Historique:
received: 27 05 2021
revised: 21 07 2021
accepted: 22 07 2021
pubmed: 30 7 2021
medline: 17 11 2021
entrez: 29 7 2021
Statut: ppublish

Résumé

Platinum complexes are currently used for breast cancer therapy, but, as with other drug classes, a series of intrinsic and acquired resistance mechanisms hinder their efficacy. To better understand the mechanisms underlying platinum complexes resistance in breast cancer, we generated a [Pt(O,O'-acac)(γ-acac)(DMS)]-resistant MCF-7, denoted as [Pt(acac)

Identifiants

DOI: 10.1016/j.bcp.2021.114702 PMID: 34324869
pubmed: 34324869
pii: S0006-2952(21)00315-4
doi: 10.1016/j.bcp.2021.114702
pii:
doi:

Substances chimiques

Platinum Compounds 0
EGFR protein, human EC 2.7.10.1
ErbB Receptors EC 2.7.10.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

114702

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

A Muscella (A)

Department of Biological and Environmental Science and Technologies (DiSTeBA), University of Salento, Via Prov. le Lecce-Monteroni, 73100 Lecce, Italy. Electronic address: antonella.muscella@unisalento.it.

E Stefàno (E)

Department of Biological and Environmental Science and Technologies (DiSTeBA), University of Salento, Via Prov. le Lecce-Monteroni, 73100 Lecce, Italy.

N Calabriso (N)

National Research Council (CNR), Campus Ecotekne, Institute of Clinical Physiology (IFC), University of Salento, Via Prov le Lecce-Monteroni, 73100 Lecce, Italy.

S A De Pascali (SA)

Department of Biological and Environmental Science and Technologies (DiSTeBA), University of Salento, Via Prov. le Lecce-Monteroni, 73100 Lecce, Italy.

F P Fanizzi (FP)

Department of Biological and Environmental Science and Technologies (DiSTeBA), University of Salento, Via Prov. le Lecce-Monteroni, 73100 Lecce, Italy.

S Marsigliante (S)

Department of Biological and Environmental Science and Technologies (DiSTeBA), University of Salento, Via Prov. le Lecce-Monteroni, 73100 Lecce, Italy.

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Classifications MeSH

questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Role of epidermal growth factor receptor...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Role of epidermal growth factor receptor...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Role of epidermal growth factor receptor...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Role of epidermal growth factor receptor...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance aux médicaments antinéoplasiques › Role of epidermal growth factor receptor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs ErbB › Role of epidermal growth factor receptor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Role of epidermal growth factor receptor...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Cellules MCF-7 › Role of epidermal growth factor receptor...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du platine › Role of epidermal growth factor receptor...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Role of epidermal growth factor receptor...