Facile one-pot synthesis of amphiphilic acid/hypoxia co-triggered degradable diblock polyprodrug for tumor selective drug delivery.
Acid/hypoxia co-triggered degradation
Drug self-delivery system
Enhanced antitumor efficacy
Ideal tumor selective cytotoxicity
Polyprodrug
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
05 Sep 2021
05 Sep 2021
Historique:
received:
15
06
2021
revised:
22
07
2021
accepted:
22
07
2021
pubmed:
30
7
2021
medline:
8
9
2021
entrez:
29
7
2021
Statut:
ppublish
Résumé
More precise drug release is expected by conjugating the drug structural units in the polyprodrugs with dynamic covalent bonds responding to different stimuli. Here, amphiphilic acid/hypoxia co-triggered degradable diblock polyprodrug was designed via a facile one-pot method with drug content of 78.6% (1.22 mmol/g) and relatively molecular weight of 2.08 × 10
Identifiants
pubmed: 34324987
pii: S0378-5173(21)00747-X
doi: 10.1016/j.ijpharm.2021.120941
pii:
doi:
Substances chimiques
Prodrugs
0
Doxorubicin
80168379AG
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
120941Informations de copyright
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