Drug delivery to the anterior segment of the eye: A review of current and future treatment strategies.
Cornea-conjunctiva barrier
Formulations
Ocular
Ophthalmic drug-delivery
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
25 Sep 2021
25 Sep 2021
Historique:
received:
21
05
2021
revised:
02
07
2021
accepted:
05
07
2021
pubmed:
30
7
2021
medline:
23
9
2021
entrez:
29
7
2021
Statut:
ppublish
Résumé
Research in the development of ophthalmic drug formulations and innovative technologies over the past few decades has been directed at improving the penetration of medications delivered to the eye. Currently, approximately 90% of all ophthalmic drug formulations (e.g. liposomes, micelles) are applied as eye drops. The major challenge of topical eye drops is low bioavailability, need for frequent instillation due to the short half-life, poor drug solubility, and potential side effects. Recent research has been focused on improving topical drug delivery devices by increasing ocular residence time, overcoming physiological and anatomical barriers, and developing medical devices and drug formulations to increase the duration of action of the active drugs. Researchers have developed innovative technologies and formulations ranging from sub-micron to macroscopic size such as prodrugs, enhancers, mucus-penetrating particles (MPPs), therapeutic contact lenses, and collagen corneal shields. Another approach towards the development of effective topical drug delivery is embedding therapeutic formulations in microdevices designed for sustained release of the active drugs. The goal is to optimize the delivery of ophthalmic medications by achieving high drug concentration with prolonged duration of action that is convenient for patients to administer.
Identifiants
pubmed: 34324989
pii: S0378-5173(21)00730-4
doi: 10.1016/j.ijpharm.2021.120924
pmc: PMC8579814
mid: NIHMS1749651
pii:
doi:
Substances chimiques
Ophthalmic Solutions
0
Prodrugs
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
120924Subventions
Organisme : NEI NIH HHS
ID : P30 EY026877
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB018842
Pays : United States
Organisme : NIBIB NIH HHS
ID : T32 EB009035
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
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