Asystolic cardiac arrest following liposomal amphotericin B infusion: anaphylaxis or compliment activation-related pseudoallergy?

Ambisome CARPA Intradermal testing LAmB Skin prick testing

Journal

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
ISSN: 1710-1484
Titre abrégé: Allergy Asthma Clin Immunol
Pays: England
ID NLM: 101244313

Informations de publication

Date de publication:
29 Jul 2021
Historique:
received: 13 01 2021
accepted: 20 07 2021
entrez: 30 7 2021
pubmed: 31 7 2021
medline: 31 7 2021
Statut: epublish

Résumé

Allergic reaction to liposomal amphotericin B is rare. We report a case of cardiac arrest in a 64-year-old woman following liposomal amphotericin B infusion, requiring resuscitation. We also present the results of subsequent skin prick and intradermal testing to liposomal amphotericin on the patient and three healthy controls, highlighting the need for further research into the immunopathogenesis of this reaction.

Identifiants

pubmed: 34325715
doi: 10.1186/s13223-021-00582-x
pii: 10.1186/s13223-021-00582-x
pmc: PMC8323293
doi:

Types de publication

Journal Article

Langues

eng

Pagination

80

Informations de copyright

© 2021. The Author(s).

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Auteurs

George P Drewett (GP)

Department of Infectious Diseases, Austin Health, Heidelberg, Australia. george.drewett@austin.org.au.
Department of Drug and Antibiotic Allergy Services, Austin Health, Heidelberg, Australia. george.drewett@austin.org.au.

Ana Copaescu (A)

Department of Drug and Antibiotic Allergy Services, Austin Health, Heidelberg, Australia.
Department of Clinical Immunology and Allergy, McGill University Health Centre, Montréal, Canada.

Joseph DeLuca (J)

Department of Drug and Antibiotic Allergy Services, Austin Health, Heidelberg, Australia.
Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Australia.

Natasha E Holmes (NE)

Department of Infectious Diseases, Austin Health, Heidelberg, Australia.
Department of Drug and Antibiotic Allergy Services, Austin Health, Heidelberg, Australia.
Data Analytics Research and Evaluation (DARE) Centre, Austin Health and University of Melbourne, Heidelberg, Australia.

Jason A Trubiano (JA)

Department of Infectious Diseases, Austin Health, Heidelberg, Australia.
Department of Drug and Antibiotic Allergy Services, Austin Health, Heidelberg, Australia.
Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Australia.

Classifications MeSH