Temporal shifts in antibiotic resistance elements govern phage-pathogen conflicts.
Bacteriolysis
Cholera
/ microbiology
Conjugation, Genetic
Drug Resistance, Bacterial
/ genetics
Epigenesis, Genetic
Feces
/ microbiology
Gammaproteobacteria
/ genetics
Genes, Bacterial
Genes, Viral
Genome, Bacterial
Genome, Viral
Host Specificity
Humans
Interspersed Repetitive Sequences
Microbial Interactions
Myoviridae
/ genetics
Vibrio cholerae
/ drug effects
Viral Proteins
/ genetics
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
30 07 2021
30 07 2021
Historique:
received:
21
12
2020
accepted:
06
06
2021
entrez:
30
7
2021
pubmed:
31
7
2021
medline:
7
8
2021
Statut:
ppublish
Résumé
Bacteriophage predation selects for diverse antiphage systems that frequently cluster on mobilizable defense islands in bacterial genomes. However, molecular insight into the reciprocal dynamics of phage-bacterial adaptations in nature is lacking, particularly in clinical contexts where there is need to inform phage therapy efforts and to understand how phages drive pathogen evolution. Using time-shift experiments, we uncovered fluctuations in
Identifiants
pubmed: 34326207
pii: 373/6554/eabg2166
doi: 10.1126/science.abg2166
pmc: PMC9064180
mid: NIHMS1795477
pii:
doi:
Substances chimiques
Viral Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI127652
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI153303
Pays : United States
Informations de copyright
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Références
Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6119-24
pubmed: 15829587
FEMS Microbiol Ecol. 2013 Feb;83(2):457-67
pubmed: 22974320
Nucleic Acids Res. 2004 Dec 02;32(21):6347-57
pubmed: 15576679
Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4652-7
pubmed: 16537404
PLoS Genet. 2019 Oct 14;15(10):e1008445
pubmed: 31609967
J Bacteriol. 2003 Sep;185(17):5045-54
pubmed: 12923077
Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1702-7
pubmed: 15653771
J Bacteriol. 2015 Nov 23;198(3):578-90
pubmed: 26598368
Appl Environ Microbiol. 2006 Apr;72(4):2849-55
pubmed: 16597991
mBio. 2014 Jan 28;5(1):e01028-13
pubmed: 24473132
Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):923-928
pubmed: 30598446
FEMS Microbiol Rev. 2014 Sep;38(5):916-31
pubmed: 24617569
Plasmid. 2006 May;55(3):173-83
pubmed: 16530834
Front Microbiol. 2016 Jan 22;7:1
pubmed: 26834723
Nucleic Acids Res. 2019 Jan 8;47(D1):D427-D432
pubmed: 30357350
Nucleic Acids Res. 2020 Jun 4;48(10):5397-5406
pubmed: 32338761
Front Microbiol. 2020 Aug 05;11:1846
pubmed: 32849443
Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11109-14
pubmed: 25024215
Nature. 2004 Jan 1;427(6969):72-4
pubmed: 14688795
Nat Rev Microbiol. 2013 Oct;11(10):675-87
pubmed: 23979432
mBio. 2020 Feb 11;11(1):
pubmed: 32047137
Front Genet. 2014 Feb 06;5:1
pubmed: 24567736
Mol Gen Genet. 1991 Aug;228(1-2):294-9
pubmed: 1886614
Nat Protoc. 2010 Apr;5(4):725-38
pubmed: 20360767
J Bacteriol. 1996 Jul;178(14):4157-65
pubmed: 8763944
Environ Microbiol Rep. 2019 Feb;11(1):15-16
pubmed: 30431224
Environ Microbiol. 2010 Feb;12(2):510-23
pubmed: 19888998
Nucleic Acids Res. 2019 Jan 10;47(1):253-265
pubmed: 30418590
Proc Natl Acad Sci U S A. 2016 May 17;113(20):5658-63
pubmed: 27140615
Nat Commun. 2018 Jun 14;9(1):2348
pubmed: 29904071
Science. 1996 Jun 28;272(5270):1910-4
pubmed: 8658163
Nature. 2010 Mar 11;464(7286):275-8
pubmed: 20182425
Clin Microbiol Rev. 1995 Jan;8(1):48-86
pubmed: 7704895
EMBO J. 2015 Jan 13;34(2):169-83
pubmed: 25452498
J Comput Biol. 2012 May;19(5):455-77
pubmed: 22506599
Nucleic Acids Res. 2021 May 7;49(8):4386-4401
pubmed: 33823541
Nat Commun. 2017 Feb 01;8:14187
pubmed: 28146150
Trends Ecol Evol. 2009 Apr;24(4):226-32
pubmed: 19201504
Front Microbiol. 2019 Sep 06;10:2072
pubmed: 31555253
Nat Rev Microbiol. 2009 Nov;7(11):828-36
pubmed: 19834481
Sci Rep. 2016 Dec 5;6(1):1
pubmed: 28442746
Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10485-90
pubmed: 26240317
Genes (Basel). 2019 Dec 16;10(12):
pubmed: 31888308
Annu Rev Microbiol. 2017 Sep 8;71:233-261
pubmed: 28657885
J Infect Dis. 2019 Oct 8;220(10):1655-1666
pubmed: 31192364
Nucleic Acids Res. 2015 Jan;43(Database issue):D298-9
pubmed: 25378308
Crit Rev Microbiol. 2020 Feb;46(1):78-99
pubmed: 32091280
Philos Trans R Soc Lond B Biol Sci. 2019 May 13;374(1772):20180089
pubmed: 30905288