Ontology of the apelinergic system in mouse pancreas during pregnancy and relationship with β-cell mass.

Animals Apelin / metabolism Apelin Receptors / metabolism Cell Proliferation Cell Separation Female Flow Cytometry Gene Expression Profiling Glucose Intolerance Insulin / metabolism Insulin Resistance Insulin-Secreting Cells / metabolism Intercellular Signaling Peptides and Proteins / metabolism Interleukin-6 / metabolism Mice Mice, Inbred C57BL Oligonucleotide Array Sequence Analysis Pancreas / embryology Placenta / metabolism Pregnancy Pregnancy, Animal

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
29 07 2021
Historique:
received: 11 04 2021
accepted: 15 07 2021
entrez: 30 7 2021
pubmed: 31 7 2021
medline: 15 12 2021
Statut: epublish

Résumé

The apelin receptor (Aplnr) and its ligands, Apelin and Apela, contribute to metabolic control. The insulin resistance associated with pregnancy is accommodated by an expansion of pancreatic β-cell mass (BCM) and increased insulin secretion, involving the proliferation of insulin-expressing, glucose transporter 2-low (Ins

Identifiants

DOI: 10.1038/s41598-021-94725-0 PMID: 34326390 PMC: PMC8322410
pubmed: 34326390
doi: 10.1038/s41598-021-94725-0
pii: 10.1038/s41598-021-94725-0
pmc: PMC8322410
doi:

Substances chimiques

Apelin 0
Apelin Receptors 0
Insulin 0
Intercellular Signaling Peptides and Proteins 0
Interleukin-6 0
apelin-13 peptide 0
interleukin-6, mouse 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

15475

Informations de copyright

© 2021. The Author(s).

Références

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Auteurs

Brenda Strutt (B)

Lawson Health Research Institute, St Joseph Health Care, 268 Grosvenor St, London, ON, N6A 4V2, Canada.

Sandra Szlapinski (S)

Lawson Health Research Institute, St Joseph Health Care, 268 Grosvenor St, London, ON, N6A 4V2, Canada.
Department of Physiology and Pharmacology, Western University, London, ON, N6A 3K7, Canada.

Thineesha Gnaneswaran (T)

Department of Physiology and Pharmacology, Western University, London, ON, N6A 3K7, Canada.

Sarah Donegan (S)

Department of Physiology and Pharmacology, Western University, London, ON, N6A 3K7, Canada.

Jessica Hill (J)

Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, EX2 5DW, UK.

Jamie Bennett (J)

Lawson Health Research Institute, St Joseph Health Care, 268 Grosvenor St, London, ON, N6A 4V2, Canada.
Life Sciences Program, School of Interdisciplinary Science, McMaster University, Hamilton, ON, L8S 4LD, Canada.

David J Hill (DJ)

Lawson Health Research Institute, St Joseph Health Care, 268 Grosvenor St, London, ON, N6A 4V2, Canada. david.hill@lawsonresearch.com.
Department of Physiology and Pharmacology, Western University, London, ON, N6A 3K7, Canada. david.hill@lawsonresearch.com.
Departments of Medicine and Paediatrics, Western University, London, ON, N6A 3K7, Canada. david.hill@lawsonresearch.com.
ORCID: 0000-0002-2490-5678

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Ontology of the apelinergic system in mouse...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Apeline › Ontology of the apelinergic system in mouse...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteur de l'apeline › Ontology of the apelinergic system in mouse...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Ontology of the apelinergic system in mouse...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Séparation cellulaire › Ontology of the apelinergic system in mouse...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytophotométrie › Cytométrie en flux › Ontology of the apelinergic system in mouse...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Ontology of the apelinergic system in mouse...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme du glucose › Hyperglycémie › Intolérance au glucose › Ontology of the apelinergic system in mouse...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Ontology of the apelinergic system in mouse...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › Ontology of the apelinergic system in mouse...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules entéroendocrines › Cellules à insuline › Ontology of the apelinergic system in mouse...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Ontology of the apelinergic system in mouse...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-6 › Ontology of the apelinergic system in mouse...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Ontology of the apelinergic system in mouse...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Ontology of the apelinergic system in mouse...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Séquençage par oligonucléotides en batterie › Ontology of the apelinergic system in mouse...
questionsmedicales.fr › Système digestif › Pancréas › Ontology of the apelinergic system in mouse...
questionsmedicales.fr › Structures de l'embryon › Placenta › Ontology of the apelinergic system in mouse...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Ontology of the apelinergic system in mouse...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Gestation animale › Ontology of the apelinergic system in mouse...