Errors in the implementation, analysis, and reporting of randomization within obesity and nutrition research: a guide to their avoidance.
Journal
International journal of obesity (2005)
ISSN: 1476-5497
Titre abrégé: Int J Obes (Lond)
Pays: England
ID NLM: 101256108
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
10
11
2020
accepted:
06
07
2021
revised:
26
06
2021
pubmed:
31
7
2021
medline:
2
2
2022
entrez:
30
7
2021
Statut:
ppublish
Résumé
Randomization is an important tool used to establish causal inferences in studies designed to further our understanding of questions related to obesity and nutrition. To take advantage of the inferences afforded by randomization, scientific standards must be upheld during the planning, execution, analysis, and reporting of such studies. We discuss ten errors in randomized experiments from real-world examples from the literature and outline best practices for their avoidance. These ten errors include: representing nonrandom allocation as random, failing to adequately conceal allocation, not accounting for changing allocation ratios, replacing subjects in nonrandom ways, failing to account for non-independence, drawing inferences by comparing statistical significance from within-group comparisons instead of between-groups, pooling data and breaking the randomized design, failing to account for missing data, failing to report sufficient information to understand study methods, and failing to frame the causal question as testing the randomized assignment per se. We hope that these examples will aid researchers, reviewers, journal editors, and other readers to endeavor to a high standard of scientific rigor in randomized experiments within obesity and nutrition research.
Identifiants
pubmed: 34326476
doi: 10.1038/s41366-021-00909-z
pii: 10.1038/s41366-021-00909-z
pmc: PMC8528702
mid: NIHMS1743032
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2335-2346Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK072476
Pays : United States
Organisme : NIDDK NIH HHS
ID : R25 DK099080
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA057030
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK040561
Pays : United States
Organisme : NHLBI NIH HHS
ID : R25 HL124208
Pays : United States
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature Limited.
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