The Impact of Chronic Kidney Disease on Peripheral Artery Disease and Peripheral Revascularization.
CKD
ESKD
PAD
albuminuria
amputations
chronic kidney disease
peripheral artery disease
Journal
International journal of general medicine
ISSN: 1178-7074
Titre abrégé: Int J Gen Med
Pays: New Zealand
ID NLM: 101515487
Informations de publication
Date de publication:
2021
2021
Historique:
received:
29
05
2021
accepted:
05
07
2021
entrez:
30
7
2021
pubmed:
31
7
2021
medline:
31
7
2021
Statut:
epublish
Résumé
Chronic kidney disease (CKD) is a clinical condition characterized by high morbidity and mortality. Globally, CKD is also increasing in prevalence and incidence. The two principal kidney measures namely estimated glomerular filtration rate (eGFR) and albuminuria have been found to be predictors of renal and cardiovascular (CV) endpoints including peripheral artery disease (PAD). The prevalence of PAD was increased in CKD patients and, particularly, in patients with more severe CKD stages. Despite the fact that revascularization strategies are suitable in CKD patients in similar fashion to non-CKD patients, few CKD patients underwent these procedures. In fact, if it is true that revascularization improves prognosis in PAD patients irrespective of baseline eGFR, it was also demonstrated that CKD patients, who underwent revascularization, were at higher risk for amputations, mortality, re-intervention and perioperative complications. With the present review article, we have examined the association between CKD, PAD and peripheral revascularization highlighting data about epidemiology, pathophysiologic mechanisms, and results from previous observational and intervention studies. We have also examined the future perspectives and challenges of research around the association between CKD and PAD.
Identifiants
pubmed: 34326661
doi: 10.2147/IJGM.S322417
pii: 322417
pmc: PMC8315808
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
3749-3759Informations de copyright
© 2021 Serra et al.
Déclaration de conflit d'intérêts
The Authors declare that there is no conflict of interest.
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