A β-Wrapin Targeting the N-Terminus of α-Synuclein Monomers Reduces Fibril-Induced Aggregation in Neurons.
molecular chaperones
nanobodies
pre-formed fibrils
protein aggregation
α-synuclein
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
04
2021
accepted:
28
05
2021
entrez:
30
7
2021
pubmed:
31
7
2021
medline:
31
7
2021
Statut:
epublish
Résumé
Reducing α-synuclein pathology constitutes a plausible strategy against Parkinson's disease. As we recently demonstrated, the β-wrapin protein AS69 binds an N-terminal region in monomeric α-synuclein, interferes with fibril nucleation, and reduces α-synuclein aggregation
Identifiants
pubmed: 34326719
doi: 10.3389/fnins.2021.696440
pmc: PMC8313869
doi:
Types de publication
Journal Article
Langues
eng
Pagination
696440Informations de copyright
Copyright © 2021 Szegő, Boß, Komnig, Gärtner, Höfs, Shaykhalishahi, Wördehoff, Saridaki, Schulz, Hoyer and Falkenburger.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Elife. 2019 Aug 21;8:
pubmed: 31389332
Science. 2012 Nov 16;338(6109):949-53
pubmed: 23161999
Front Neurosci. 2018 May 23;12:344
pubmed: 29875627
J Neurochem. 2016 Dec;139(5):848-857
pubmed: 27638043
Neurobiol Aging. 2013 Feb;34(2):589-601
pubmed: 22579457
J Neuroinflammation. 2018 May 1;15(1):129
pubmed: 29716614
Nat Protoc. 2014 Sep;9(9):2135-46
pubmed: 25122523
J Biol Chem. 2017 Aug 11;292(32):13482-13497
pubmed: 28611062
Neurology. 2012 Dec 11;79(24):2298-9
pubmed: 23152588
Angew Chem Int Ed Engl. 2015 Jul 20;54(30):8837-40
pubmed: 26119103
J Neurosci. 2019 Jun 26;39(26):5080-5094
pubmed: 31036761
J Biol Chem. 2021 Jan-Jun;296:100273
pubmed: 33428941
J Neurosci. 2009 Mar 18;29(11):3365-73
pubmed: 19295143
J Neurosci. 2014 Feb 5;34(6):2037-50
pubmed: 24501346
Nat Rev Neurosci. 2005 Jan;6(1):11-22
pubmed: 15611723
Sci Rep. 2019 Jan 24;9(1):544
pubmed: 30679445
Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):4971-4982
pubmed: 32075919
J Neurochem. 2001 May;77(4):1181-4
pubmed: 11359883
J Neurochem. 2013 Jul;126(1):131-44
pubmed: 23363402
J Parkinsons Dis. 2019;9(s2):S281-S295
pubmed: 31498132
J Vis Exp. 2018 Jun 5;(136):
pubmed: 29939190
Methods Mol Biol. 2019;1948:45-57
pubmed: 30771169
J Exp Med. 2012 May 7;209(5):975-86
pubmed: 22508839
Chem Commun (Camb). 2018 Aug 2;54(63):8667-8684
pubmed: 29978862
Nat Struct Mol Biol. 2020 Mar;27(3):249-259
pubmed: 32157247
J Neurochem. 2009 Jan;108(1):139-46
pubmed: 19094062
Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6506-E6515
pubmed: 27708160
Protein Eng Des Sel. 2014 Dec;27(12):473-9
pubmed: 25332193
Cell Death Dis. 2015 Jul 09;6:e1811
pubmed: 26158517
Angew Chem Int Ed Engl. 2014 Apr 14;53(16):4227-30
pubmed: 24623599
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Neurobiol Dis. 2012 Jan;45(1):591-600
pubmed: 22001606
Mov Disord. 2017 Sep;32(9):1264-1310
pubmed: 28887905
J Neurosci. 2000 Sep 1;20(17):6365-73
pubmed: 10964942
Acta Neuropathol. 2019 Oct;138(4):535-550
pubmed: 31254094
J Am Assoc Lab Anim Sci. 2012 May;51(3):311-21
pubmed: 22776188
J Neuroinflammation. 2019 Dec 3;16(1):250
pubmed: 31796095
Cell Rep. 2016 Sep 20;16(12):3373-3387
pubmed: 27653697
Acta Neuropathol Commun. 2020 Aug 28;8(1):150
pubmed: 32859276
J Neurosci. 2016 Jul 20;36(29):7693-706
pubmed: 27445146
Cell Rep. 2019 Jul 2;28(1):65-77.e6
pubmed: 31269451
Cell Rep. 2015 Mar 3;10(8):1252-60
pubmed: 25732816
Neurobiol Dis. 2020 Dec;146:105086
pubmed: 32971232
Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7813-7818
pubmed: 29991596
Sci Rep. 2020 Jul 22;10(1):12175
pubmed: 32699326
Neurobiol Dis. 2019 Oct;130:104525
pubmed: 31276792
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
Acta Neuropathol. 2006 Feb;111(2):101-8
pubmed: 16482476
Neuroscience. 2009 Jun 2;160(4):796-804
pubmed: 19272424
Acta Neuropathol Commun. 2021 Feb 25;9(1):31
pubmed: 33632316
Acta Neuropathol. 2017 Oct;134(4):629-653
pubmed: 28527044
Front Neurosci. 2019 Nov 01;13:1124
pubmed: 31749672