Acute TBK1/IKK-ε Inhibition Enhances the Generation of Disease-Associated Microglia-Like Phenotype Upon Cortical Stab-Wound Injury.
TBK1
amlexanox
microglia
neuroinflammation
stab wound injury
traumatic brain injury
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
03
2021
accepted:
21
06
2021
entrez:
30
7
2021
pubmed:
31
7
2021
medline:
31
7
2021
Statut:
epublish
Résumé
Traumatic brain injury has a poorer prognosis in elderly patients, possibly because of the enhanced inflammatory response characteristic of advanced age, known as "inflammaging." Recently, reduced activation of the TANK-Binding-Kinase 1 (Tbk1) pathway has been linked to age-associated neurodegeneration and neuroinflammation. Here we investigated how the blockade of Tbk1 and of the closely related IKK-ε by the small molecule Amlexanox could modify the microglial and immune response to cortical stab-wound injury in mice. We demonstrated that Tbk1/IKK-ε inhibition resulted in a massive expansion of microglial cells characterized by the TMEM119
Identifiants
pubmed: 34326766
doi: 10.3389/fnagi.2021.684171
pmc: PMC8313992
doi:
Types de publication
Journal Article
Langues
eng
Pagination
684171Informations de copyright
Copyright © 2021 Rehman, Tar, Olamide, Li, Kassubek, Böckers, Weishaupt, Ludolph, Wiesner and Roselli.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
EMBO Mol Med. 2020 Sep 7;12(9):e12308
pubmed: 32790063
Neuropathology. 2016 Feb;36(1):39-49
pubmed: 26250788
J Cell Mol Med. 2020 Oct;24(19):11573-11582
pubmed: 32858764
Mol Neurodegener. 2018 May 21;13(1):24
pubmed: 29784049
Nat Cell Biol. 2018 Dec;20(12):1389-1399
pubmed: 30420664
J Clin Invest. 2021 Jan 4;131(1):
pubmed: 32990676
J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S4-9
pubmed: 24833586
J Neuroinflammation. 2020 May 28;17(1):168
pubmed: 32466767
Brain Commun. 2020 Aug 21;2(2):fcaa133
pubmed: 33005894
Immunology. 2013 Mar;138(3):198-207
pubmed: 23181380
Nat Med. 2013 Mar;19(3):313-21
pubmed: 23396211
Aging (Albany NY). 2012 Mar;4(3):166-75
pubmed: 22411934
Cell. 2017 Jun 15;169(7):1276-1290.e17
pubmed: 28602351
Epilepsia. 2003;44(s10):2-10
pubmed: 14511388
EMBO Mol Med. 2020 Feb 7;12(2):e10491
pubmed: 31930708
Science. 2013 Jan 11;339(6116):156-61
pubmed: 23307732
PLoS One. 2015 Mar 20;10(3):e0118640
pubmed: 25794104
J Biol Chem. 2009 May 22;284(21):14136-46
pubmed: 19307177
Neuron. 2020 Dec 9;108(5):801-821
pubmed: 33096024
Mol Neurobiol. 2021 May;58(5):2435-2446
pubmed: 33439438
J Neurosci Res. 2020 Feb;98(2):284-298
pubmed: 30942936
Cell. 2018 May 17;173(5):1073-1081
pubmed: 29775591
J Neuroinflammation. 2020 Apr 14;17(1):115
pubmed: 32290848
J Am Geriatr Soc. 2006 Oct;54(10):1590-5
pubmed: 17038079
Immunity. 2019 Jan 15;50(1):253-271.e6
pubmed: 30471926
Theranostics. 2018 Sep 09;8(17):4633-4648
pubmed: 30279728
J Neuroinflammation. 2019 Mar 12;16(1):60
pubmed: 30871598
Cell Rep. 2019 Apr 23;27(4):1293-1306.e6
pubmed: 31018141
Cell Rep. 2019 May 14;27(7):2002-2013.e5
pubmed: 31091440
J Neurotrauma. 2018 Oct 1;35(19):2317-2329
pubmed: 29463176
FASEB J. 2013 Jul;27(7):2829-44
pubmed: 23608145
Glia. 2015 Apr;63(4):611-25
pubmed: 25471735
Elife. 2019 Mar 26;8:
pubmed: 30910011
Mol Brain. 2017 Jun 7;10(1):20
pubmed: 28592261
Int J Mol Sci. 2017 Apr 05;18(4):
pubmed: 28379162
Int J Epidemiol. 1990 Mar;19(1):133-40
pubmed: 2351508
Science. 2015 Mar 13;347(6227):aaa2630
pubmed: 25636800
J Neurosci. 2020 Feb 26;40(9):1956-1974
pubmed: 31980586
Neurobiol Aging. 2009 May;30(5):759-68
pubmed: 17905482
Brain. 2016 Mar;139(Pt 3):653-61
pubmed: 26912633
Nat Immunol. 2012 Nov;13(11):1101-9
pubmed: 23023393
Immunity. 2017 Sep 19;47(3):566-581.e9
pubmed: 28930663
Neuron. 2020 Jun 3;106(5):789-805.e5
pubmed: 32220666
Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):
pubmed: 33766915
Neurol Neuroimmunol Neuroinflamm. 2020 Jul 15;7(5):
pubmed: 32669313
Cell. 2017 Aug 10;170(4):649-663.e13
pubmed: 28802038
Neuron. 2018 Mar 7;97(5):1032-1048.e5
pubmed: 29518357
J Neuroinflammation. 2019 Mar 1;16(1):52
pubmed: 30823934
J Inflamm (Lond). 2018 Nov 16;15:23
pubmed: 30473634
Am J Epidemiol. 1984 Feb;119(2):186-201
pubmed: 6695898
Nat Neurosci. 2018 Apr;21(4):541-551
pubmed: 29507414
Hum Mol Genet. 2015 Aug 1;24(15):4429-42
pubmed: 25972374
Microvasc Res. 2015 Mar;98:68-73
pubmed: 25582076
Glia. 2021 Feb;69(2):326-345
pubmed: 32865285
Cell. 2018 Sep 6;174(6):1477-1491.e19
pubmed: 30146158
Neuron. 2020 Mar 4;105(5):837-854.e9
pubmed: 31902528
Neuron. 2021 Apr 7;109(7):1100-1117.e10
pubmed: 33606969
Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12414-9
pubmed: 23836654
EMBO Rep. 2018 May;19(5):
pubmed: 29632244
EMBO J. 2018 Aug 15;37(16):
pubmed: 29875132
Front Mol Neurosci. 2017 Jun 30;10:206
pubmed: 28713239
Int J Mol Sci. 2017 May 08;18(5):
pubmed: 28481289
Life Sci Alliance. 2020 Sep 8;3(11):
pubmed: 32900826
Front Cell Neurosci. 2019 May 03;13:181
pubmed: 31130847
Toxicology. 2020 Nov;444:152579
pubmed: 32905826
Neuron. 2017 Dec 20;96(6):1290-1302.e6
pubmed: 29268096
Front Aging Neurosci. 2020 Sep 29;12:566922
pubmed: 33132897
Lancet Neurol. 2019 Mar;18(3):286-295
pubmed: 30784557
Acta Neuropathol. 2020 Oct;140(4):513-534
pubmed: 32772264
Stroke. 2021 Jan;52(2):687-698
pubmed: 33412903
Cell Rep. 2020 Jun 30;31(13):107843
pubmed: 32610143
J Exp Med. 2019 Feb 4;216(2):267-278
pubmed: 30635357
Nat Commun. 2015 Jan 21;6:6074
pubmed: 25606824
Acta Neuropathol Commun. 2021 Jan 5;9(1):1
pubmed: 33402227
Neuron. 2021 Apr 21;109(8):1283-1301.e6
pubmed: 33675684
Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):E1738-46
pubmed: 26884166
Mult Scler. 2018 Mar;24(3):290-300
pubmed: 28277099
Cell Rep. 2020 Apr 7;31(1):107492
pubmed: 32268090
Brain Behav Immun. 2019 Oct;81:228-246
pubmed: 31207335
Neurobiol Aging. 2019 May;77:194-206
pubmed: 30904769
Nat Rev Endocrinol. 2018 Oct;14(10):576-590
pubmed: 30046148
Exp Neurol. 2018 Jan;299(Pt A):15-25
pubmed: 28941811
Front Cell Neurosci. 2019 Jan 10;12:523
pubmed: 30687013
EMBO J. 2018 Apr 13;37(8):
pubmed: 29496741
Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):
pubmed: 33785602
J Clin Exp Dent. 2016 Oct 1;8(4):e368-e372
pubmed: 27703603
J Neurotrauma. 2017 Jan 15;34(2):423-435
pubmed: 26976047
Immunity. 2021 Jan 12;54(1):99-115.e12
pubmed: 33271118
Cell Metab. 2017 Jul 5;26(1):157-170.e7
pubmed: 28683283
Sci Rep. 2021 May 13;11(1):10299
pubmed: 33986412
EMBO Mol Med. 2019 Jun;11(6):
pubmed: 31122931
Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8788-E8797
pubmed: 28904096
Nat Immunol. 2003 May;4(5):491-6
pubmed: 12692549
Acta Neurochir (Wien). 2015 Oct;157(10):1683-96
pubmed: 26269030
Nat Neurosci. 2017 Aug;20(8):1162-1171
pubmed: 28671693
Neuropharmacology. 2019 Mar 1;146:198-211
pubmed: 30528326
Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):7611-7616
pubmed: 29967166