Translational GTPase BipA Is Involved in the Maturation of a Large Subunit of Bacterial Ribosome at Suboptimal Temperature.

BipA conditional protein expression large subunit maturation ribosome biogenesis stress response suboptimal temperature growth

Journal

Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977

Informations de publication

Date de publication:
2021
Historique:
received: 26 03 2021
accepted: 09 06 2021
entrez: 30 7 2021
pubmed: 31 7 2021
medline: 31 7 2021
Statut: epublish

Résumé

BPI-inducible protein A (BipA), a highly conserved paralog of the well-known translational GTPases LepA and EF-G, has been implicated in bacterial motility, cold shock, stress response, biofilm formation, and virulence. BipA binds to the aminoacyl-(A) site of the bacterial ribosome and establishes contacts with the functionally important regions of both subunits, implying a specific role relevant to the ribosome, such as functioning in ribosome biogenesis and/or conditional protein translation. When cultured at suboptimal temperatures, the

Identifiants

pubmed: 34326822
doi: 10.3389/fmicb.2021.686049
pmc: PMC8313970
doi:

Types de publication

Journal Article

Langues

eng

Pagination

686049

Informations de copyright

Copyright © 2021 Goh, Ero, Yan, Park, Kundukad, Zheng, Sze and Gao.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Kwok Jian Goh (KJ)

School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

Rya Ero (R)

School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

Xin-Fu Yan (XF)

School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

Jung-Eun Park (JE)

School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

Binu Kundukad (B)

Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore, Singapore.

Jun Zheng (J)

Faculty of Health Sciences, University of Macau, Macau, China.

Siu Kwan Sze (SK)

School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

Yong-Gui Gao (YG)

School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

Classifications MeSH