Advances in Development and Application of Influenza Vaccines.
Animals
Chickens
Forecasting
Genetic Vectors
Humans
Influenza A virus
/ genetics
Influenza Vaccines
Influenza in Birds
/ prevention & control
Influenza, Human
/ epidemiology
Poultry Diseases
/ prevention & control
Seasons
Vaccine Development
/ trends
Vaccines, Attenuated
Vaccines, Inactivated
Vaccines, Subunit
Vaccines, Synthetic
Vaccines, Virosome
Virion
influenza vaccines
seasonal influenza vaccine strains selection
subunit vaccines
universal influenza vaccines development
viral vectored vaccines
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
19
05
2021
accepted:
24
06
2021
entrez:
30
7
2021
pubmed:
31
7
2021
medline:
21
12
2021
Statut:
epublish
Résumé
Influenza A virus is one of the most important zoonotic pathogens that can cause severe symptoms and has the potential to cause high number of deaths and great economic loss. Vaccination is still the best option to prevent influenza virus infection. Different types of influenza vaccines, including live attenuated virus vaccines, inactivated whole virus vaccines, virosome vaccines, split-virion vaccines and subunit vaccines have been developed. However, they have several limitations, such as the relatively high manufacturing cost and long production time, moderate efficacy of some of the vaccines in certain populations, and lack of cross-reactivity. These are some of the problems that need to be solved. Here, we summarized recent advances in the development and application of different types of influenza vaccines, including the recent development of viral vectored influenza vaccines. We also described the construction of other vaccines that are based on recombinant influenza viruses as viral vectors. Information provided in this review article might lead to the development of safe and highly effective novel influenza vaccines.
Identifiants
pubmed: 34326849
doi: 10.3389/fimmu.2021.711997
pmc: PMC8313855
doi:
Substances chimiques
Influenza Vaccines
0
Vaccines, Attenuated
0
Vaccines, Inactivated
0
Vaccines, Subunit
0
Vaccines, Synthetic
0
Vaccines, Virosome
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
711997Informations de copyright
Copyright © 2021 Chen, Wang, Zhang and Ly.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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