Structural Dynamics and Perspectives of Vitamin B6 Biosynthesis Enzymes in
Pdx1
Pdx2
Plasmodium falciparum
malaria
pyridoxal 5-phosphate
vitamin B6
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2021
2021
Historique:
received:
30
03
2021
accepted:
28
06
2021
entrez:
30
7
2021
pubmed:
31
7
2021
medline:
5
8
2021
Statut:
epublish
Résumé
Malaria is still today one of the most concerning diseases, with 219 million infections in 2019, most of them in Sub-Saharan Africa and Latin America, causing approx. 409,000 deaths per year. Despite the tremendous advances in malaria treatment and prevention, there is still no vaccine for this disease yet available and the increasing parasite resistance to already existing drugs is becoming an alarming issue globally. In this context, several potential targets for the development of new drug candidates have been proposed and, among those, the
Identifiants
pubmed: 34327152
doi: 10.3389/fcimb.2021.688380
pmc: PMC8313854
doi:
Substances chimiques
Vitamin B 6
8059-24-3
Glutaminase
EC 3.5.1.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
688380Informations de copyright
Copyright © 2021 Barra, Ullah, Morão, Wrenger, Betzel and Nascimento.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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