Prognostic value of DCE-CT-derived blood volume and flow compared to core biopsy microvessel density in patients with metastatic renal cell carcinoma.
Blood volume
Carcinoma (renal cell)
Microvascular density
Prognosis
Tomography (x-ray computed)
Journal
European radiology experimental
ISSN: 2509-9280
Titre abrégé: Eur Radiol Exp
Pays: England
ID NLM: 101721752
Informations de publication
Date de publication:
30 07 2021
30 07 2021
Historique:
received:
12
03
2021
accepted:
01
07
2021
entrez:
30
7
2021
pubmed:
31
7
2021
medline:
3
2
2022
Statut:
epublish
Résumé
Angiogenesis is prominent in metastatic renal cell carcinoma (mRCC). We compared two angiogenesis assessment methods: dynamic contrast-enhanced computed tomography (DCE-CT)-derived blood volume (BV) and blood flow (BF) and core biopsy microvessel density (MVD). As planned in DaRenCa Study-1 study, DCE-CT and core biopsy were performed from the same tumour/metastasis at baseline. MVD was assessed by CD34 immunostaining in tumour (CD34-index At baseline, 25 patients had analysable scans and tissue. BV Differently from MVD, DCE-CT-derived BV and BF had prognostic impact and may better reflect angiogenesis in mRCC. NCT01274273.
Sections du résumé
BACKGROUND
Angiogenesis is prominent in metastatic renal cell carcinoma (mRCC). We compared two angiogenesis assessment methods: dynamic contrast-enhanced computed tomography (DCE-CT)-derived blood volume (BV) and blood flow (BF) and core biopsy microvessel density (MVD).
METHODS
As planned in DaRenCa Study-1 study, DCE-CT and core biopsy were performed from the same tumour/metastasis at baseline. MVD was assessed by CD34 immunostaining in tumour (CD34-index
RESULTS
At baseline, 25 patients had analysable scans and tissue. BV
CONCLUSIONS
Differently from MVD, DCE-CT-derived BV and BF had prognostic impact and may better reflect angiogenesis in mRCC.
TRIAL REGISTRATION
NCT01274273.
Identifiants
pubmed: 34327591
doi: 10.1186/s41747-021-00232-2
pii: 10.1186/s41747-021-00232-2
pmc: PMC8322257
doi:
Substances chimiques
Contrast Media
0
Banques de données
ClinicalTrials.gov
['NCT01274273']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
32Informations de copyright
© 2021. The Author(s).
Références
J Immunother Cancer. 2020 Jul;8(2):
pubmed: 32661118
N Engl J Med. 2021 Apr 8;384(14):1289-1300
pubmed: 33616314
Acta Oncol. 2018 May;57(5):589-594
pubmed: 29392960
Cancer Res. 1998 Aug 15;58(16):3598-602
pubmed: 9721867
N Engl J Med. 2019 Mar 21;380(12):1116-1127
pubmed: 30779529
Abdom Imaging. 2010 Oct;35(5):622-8
pubmed: 19763683
Nat Rev Urol. 2010 May;7(5):245-57
pubmed: 20448658
Invest Radiol. 2017 Feb;52(2):103-110
pubmed: 27513367
Am J Pathol. 1993 Aug;143(2):401-9
pubmed: 7688183
Br J Radiol. 2003 Apr;76(904):220-31
pubmed: 12711641
Eur Urol Oncol. 2020 Aug;3(4):530-539
pubmed: 32037304
J Natl Cancer Inst. 1992 Dec 16;84(24):1875-87
pubmed: 1281237
Invest Radiol. 2014 Sep;49(9):601-7
pubmed: 24691140
Clin Cancer Res. 2018 Jan 1;24(1):217-223
pubmed: 29066509
Expert Rev Anticancer Ther. 2019 Mar;19(3):245-257
pubmed: 30678509
Eur Radiol. 2006 Nov;16 Suppl 7:M37-43
pubmed: 18655265
Clin Cancer Res. 2008 Aug 1;14(15):4726-34
pubmed: 18676741
Cancer. 1997 Dec 15;80(12):2257-62
pubmed: 9404702
Semin Oncol. 2000 Apr;27(2):204-12
pubmed: 10768599
Br J Cancer. 2007 Jun 18;96(12):1888-95
pubmed: 17505508
Lab Invest. 2012 Jan;92(1):46-56
pubmed: 22042086
Eur Radiol. 2012 Jul;22(7):1430-41
pubmed: 22367468
J Clin Oncol. 2009 Dec 1;27(34):5794-9
pubmed: 19826129
Eur J Cancer. 2016 Jul;62:132-7
pubmed: 27189322
Hum Pathol. 2007 Oct;38(10):1454-62
pubmed: 17889675
Cell. 2018 Apr 19;173(3):581-594.e12
pubmed: 29656895
AJR Am J Roentgenol. 2006 May;186(5):1423-30
pubmed: 16632740
Br J Cancer. 2014 May 27;110(11):2700-7
pubmed: 24786599
Lancet Oncol. 2017 Mar;18(3):e143-e152
pubmed: 28271869
Br J Radiol. 2018 Feb;91(1082):20160795
pubmed: 29144161
N Engl J Med. 2019 Mar 21;380(12):1103-1115
pubmed: 30779531
Urology. 1995 Jul;46(1):27-30
pubmed: 7604476
World J Surg Oncol. 2011 Dec 02;9:158
pubmed: 22133010
BJU Int. 2008 Mar;101(6):758-64
pubmed: 18070177
Clin Genitourin Cancer. 2017 Feb;15(1):e1-e7
pubmed: 27444986
Transl Oncol. 2020 Oct;13(10):100829
pubmed: 32653813
Lab Invest. 2008 Sep;88(9):962-72
pubmed: 18626467